Rearrangement of the beta chain of the T cell antigen receptor and immunoglobulin genes in lymphoproliferative disorders

The Journal of Clinical Investigation
H GriesserT W Mak

Abstract

55 samples representing Hodgkin's and non-Hodgkin's lymphoma and other hyperplastic lesions of the lymph node were examined for rearrangement of the beta chain of the T cell antigen receptor (TcR) and Ig genes. In non-Hodgkin's lymphoma, rearrangement of TcR beta was found in all 14 T cell lymphomas and in two of the seven B cell lymphomas. Ig gene rearrangement was found in none of the 14 T cell lymphomas and in all seven B cell lymphomas. We also examined DNA from lymph nodes in which the lineage of the malignant cell is not clear. Rearrangement of TcR beta was found in all five lymphoepitheloid cell (Lennert's) lymphomas; four of eight Hodgkin's lymphomas; seven of ten Ki 1+ lymphomas; and all nine cases of angioimmunoblastic lymphoadenopathy (AIL). Ig gene rearrangement was found in none of five lymphoepitheloid cell lymphomas; none of eight Hodgkin's lymphomas; three of ten Ki 1+ lymphomas; and four of nine cases of AIL. These findings indicate that genetic studies of TcR and Ig genes are useful in identifying the presence of a clonal population in a lymph node, in determining the extent of the clonal population, and aid in identifying lineage. Of special interest was the finding that some cases of Hodgkin's lymphoma and A...Continue Reading

References

Jan 2, 1975·The New England Journal of Medicine·R J Lukes, B H Tindle
May 23, 1975·Deutsche medizinische Wochenschrift·T Radaszkiewicz, K Lennert
Apr 1, 1985·The Journal of Experimental Medicine·M H SiegelmanJ Sklar
Feb 1, 1986·The Journal of Experimental Medicine·G Y ChengE A McCulloch
Jan 1, 1986·Annual Review of Immunology·M KronenbergN Shastri
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M D MindenT Mak
Sep 1, 1985·The Journal of Experimental Medicine·P G PelicciR Dalla Favera
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·H KnechtK Lennert
Jun 1, 1974·Lancet·G FrizzeraH Rappaport
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S J KorsmeyerP Leder
Dec 29, 1983·The New England Journal of Medicine·A ArnoldS J Korsmeyer
Dec 1, 1984·Cancer Genetics and Cytogenetics·E Gödde-Salz, E W Schwarze
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J F GusellaD Housman

❮ Previous
Next ❯

Citations

Sep 1, 1991·Annals of Neurology·S G LynchM Leppert
Nov 1, 1988·Cancer Metastasis Reviews·S WatanabeM Shimoyama
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·A CarboneM Boiocchi
Jan 1, 1990·Cancer Genetics and Cytogenetics·B SchlegelbergerW Grote
Nov 1, 1990·Cancer Genetics and Cytogenetics·B SchlegelbergerK Lennert
Feb 23, 1989·The New England Journal of Medicine·E S Jaffe
Dec 1, 1990·British Journal of Haematology·R M LowenthalG M Woods
Apr 1, 1991·Histopathology·J P MerlioJ Beylot
Jun 1, 1991·Acta Paediatrica Japonica; Overseas Edition·S NakazonoM Tokunaga
Apr 1, 1993·Journal of Clinical Pathology·C A AngelI Lauder
Jan 1, 1991·Leukemia & Lymphoma·H TeschV Diehl
Jan 1, 1992·Cancer Investigation·R M Lebovitz, S Albrecht
Jan 1, 1992·Cancer Investigation·H T LynchJ F Lynch
Jun 1, 1987·Blood Reviews·M D Reis, T W Mak
Oct 1, 1989·British Journal of Haematology·C A HansonG Frizzera
Nov 1, 1988·International Journal of Cell Cloning·S R NewcomC Phillips
Jan 1, 1990·Leukemia Research·H TeschV Diehl
Jan 1, 1990·Critical Reviews in Oncology/hematology·J CossmanL J Medeiros
Mar 15, 1988·Cancer·B SchnitzerD Ginsburg
Nov 1, 1989·The British Journal of Dermatology·A C Feller, W Sterry
Jan 1, 1989·Journal of Clinical Laboratory Analysis·T SunV Vinciguerra
Mar 1, 1989·International Journal of Dermatology·M YamadaF Inoue
Mar 1, 1991·Journal of Clinical Pathology·A D BullJ H Smith

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.