Reassessing GWAS findings for the shared genetic basis of insomnia and restless legs syndrome

Sleep
Maryam El GewelySimon C Warby

Abstract

Two genome-wide association studies (GWAS) suggest that insomnia and restless legs syndrome (RLS) share a common genetic basis. While the identified genetic variation in the MEIS1 gene was previously associated with RLS, the two GWAS suggest a novel and independent association with insomnia symptoms. To test the potential pleiotropic effect of MEIS1, we genotyped three MEIS1 variants in 646 chronic insomnia disorder (CID) patients with and without RLS. To confirm our results, we compared the allelic and genotypic distributions of the CID cohort with ethnically matched controls and RLS cases in the French Canadian cohort. The CID cohort was diagnosed by sleep medicine specialists and 26% of the sample received the combined diagnosis of CID+RLS. We find significant differences in allele and genotype distributions between CID-only and CID+RLS groups, suggesting that MEIS1 is only associated with RLS. Genotype distributions and minor allele frequencies of the three MEIS1 SNPs of the CID-only and control groups were similar (rs113851554: 5.3% vs. 5.6%; rs2300478: 25.3% vs. 26.5%; rs12469063: 23.6% vs. 24.4%; all p > 0.05). Likewise, there were no differences between CID+RLS and RLS-only groups (all p > 0.05). In conclusion, our data...Continue Reading

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Citations

Sep 26, 2019·Frontiers in Neurology·Faezeh SaraylooGuy A Rouleau
Oct 22, 2020·Curēus·Mohammad D MemonIvan Cancarevic
Jun 2, 2021·The Journal of Clinical Investigation·Navid KoleiniHossein Ardehali
Nov 5, 2021·Nature Reviews. Disease Primers·Mauro ManconiYves Dauvilliers
Nov 5, 2021·Psychiatry Investigation·Jae Eun SeoHeon-Jeong Lee
Jun 26, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Jonathan FoldagerLogan D Schneider

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