Reassessing the Evolutionary Importance of Inflammasomes

The Journal of Immunology : Official Journal of the American Association of Immunologists
Vivien I Maltez, Edward A Miao

Abstract

Inflammasomes monitor the cytosol for microbial contamination or perturbation and, thus, are predicted to provide potent defense against infection. However, the compendium of data from murine infection models suggests that inflammasomes merely delay the course of disease, allowing the host time to mount an adaptive response. Interpretations of such results are confounded by inflammasome-evasion strategies of vertebrate-adapted pathogens. Conversely, environmental opportunistic pathogens have not evolved in the context of inflammasomes and, therefore, are less likely to evade them. Indeed, opportunistic pathogens do not normally cause disease in wild-type animals. Accordantly, the extreme virulence of two opportunistic bacterial pathogens, Burkholderia thailandensis and Chromobacterium violaceum, is fully counteracted by inflammasomes in murine models. This leads us to propose a new hypothesis: perhaps animals maintain inflammasomes over evolutionary time not to defend against vertebrate-adapted pathogens but instead to counteract infection by a plethora of undiscovered opportunistic pathogens residing in the environment.

References

Jun 1, 1992·The Journal of Experimental Medicine·J T Harty, M J Bevan
Jun 11, 1999·Immunology and Cell Biology·S TurnerJ Ruby
Jul 19, 2000·The Journal of Experimental Medicine·D M MonackS Falkow
Jan 22, 2004·International Immunology·Noriko M TsujiRichard A Flavell
Oct 19, 2005·The Journal of Experimental Medicine·Sanjeev MariathasanDenise M Monack
May 24, 2006·The Journal of Experimental Medicine·Maria Lara-TejeroJorge E Galán
Sep 29, 2006·Cellular Microbiology·Barbara AlbigerBirgitta Henriques-Normark
Jan 14, 2009·The Journal of Experimental Medicine·Takeshi IchinoheAkiko Iwasaki
Jan 31, 2009·Infection and Immunity·Katrin BreitbachIvo Steinmetz
Jul 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen B WillinghamJenny P-Y Ting
Aug 5, 2009·PloS One·Catherine DostertJurg Tschopp
Aug 22, 2009·PLoS Pathogens·Marina Tiemi ShioMartin Olivier
Dec 2, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jill K TerraKenneth A Bradley
Dec 2, 2009·European Journal of Immunology·Thornik ReimerGabriel Núñez
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Edward A MiaoAlan Aderem
Mar 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katrin D Mayer-BarberAlan Sher
Mar 30, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia TomaToshihiko Suzuki
Mar 31, 2010·Nature Immunology·Teresa Fernandes-AlnemriEmad S Alnemri
Mar 1, 2009·Journal of Fish Biology·K Sakamaki, Y Satou
Jan 22, 2011·Science·Sean M GregoryBlossom Damania
May 4, 2011·European Journal of Immunology·Sarah E WarrenAlan Aderem
Jun 18, 2011·European Journal of Immunology·Frank L van de VeerdonkThirumala-Devi Kanneganti
Jul 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·John-Demian SauerDaniel A Portnoy
Oct 18, 2011·Nature·Nobuhiko KayagakiVishva M Dixit
Nov 1, 2011·Journal of the Chinese Medical Association : JCMA·Ching-Huei Yang, Yi-Hwei Li
Jan 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandro CostaConcetta Beninati
May 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shanshan CaiSamithamby Jeyaseelan
Jun 5, 2012·Nucleic Acids Research·Panu ArtimoHeinz Stockinger
Jun 15, 2012·International Immunology·Hiroyuki SaigaKiyoshi Takeda
Aug 21, 2012·Nature·Jakob von MoltkeRussell E Vance
Sep 14, 2012·The New England Journal of Medicine·W Joost WiersingaSharon J Peacock
Oct 10, 2012·The Journal of Experimental Medicine·Rebecca L BrunetteDaniel B Stetson

❮ Previous
Next ❯

Citations

Feb 1, 2017·Nature Reviews. Immunology·Ine JorgensenEdward A Miao
Aug 4, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nikolett LénártÁdám Dénes
Dec 23, 2016·Brain Pathology·Claire S WhiteJack Rivers-Auty
Nov 28, 2017·Frontiers in Microbiology·Juliana H Batista, José F da Silva Neto
Sep 11, 2019·Cold Spring Harbor Perspectives in Biology·Carolyn A Lacey, Edward A Miao
Jun 13, 2020·Journal of Leukocyte Biology·Pontus Orning, Egil Lien
Jan 10, 2017·International Journal of Molecular Sciences·Michael J D Daniels, David Brough
Jul 22, 2018·Nature Reviews. Drug Discovery·Matthew S J ManganEicke Latz
Sep 3, 2020·Nature Reviews. Molecular Cell Biology·Sammy BedouiAndreas Strasser
Jul 28, 2020·Journal of Clinical Medicine·Lucia LonghitanoGiuseppe Alberto Palumbo
Dec 22, 2017·Nature Communications·Randilea D NicholsRussell E Vance
Sep 26, 2020·Frontiers in Immunology·Changhoon OhYoussef Aachoui
Nov 16, 2020·The FEBS Journal·Vladimir Lažetić, Emily R Troemel
Dec 29, 2020·Veterinary Pathology·Martha A DelaneyCharles W Frevert
Jan 27, 2021·Nature Immunology·Andrea L Graham
Jun 29, 2021·Biochemistry and Biophysics Reports·Ju-Hee KangMijung Yim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Hospital Medicine
Hoi-Poh TeeSoon-Hin How
Research in Veterinary Science
E A Wijewanta, S G Wettimuny
American Journal of Clinical Pathology
R M Dauphinais, G G Robben
© 2022 Meta ULC. All rights reserved