Reassessing the impact of intraoperative electrocorticography on postoperative outcome of patients undergoing standard temporal lobectomy for MRI-negative temporal lobe epilepsy

Journal of Neurosurgery
Sanjeet S GrewalJamie J Van Gompel

Abstract

Almost 30% of the patients with suspected temporal lobe epilepsy (TLE) have normal results on MRI. Success rates for resection of MRI-negative TLE are less favorable, ranging from 36% to 76%. Herein the authors describe the impact of intraoperative electrocorticography (ECoG) augmented by opioid activation and its effect on postoperative seizure outcome. Adult and pediatric patients with medically resistant MRI-negative TLE who underwent standardized ECoG at the time of their elective anterior temporal lobectomy (ATL) with amygdalohippocampectomy between 1990 and 2016 were included in this study. Seizure recurrence comprised the primary outcome of interest and was assessed using Kaplan-Meier and multivariable Cox regression analysis plots based on distribution of interictal epileptiform discharges (IEDs) recorded on scalp electroencephalography, baseline and opioid-induced IEDs on ECoG, and extent of resection. Of the 1144 ATLs performed at the authors' institution between 1990 and 2016, 127 (11.1%) patients (81 females) with MRI-negative TLE were eligible for this study. Patients with complete resection of tissue generating IED recorded on intraoperative ECoG were less likely to have seizure recurrence compared to those with i...Continue Reading

References

Jul 30, 2004·Brain : a Journal of Neurology·R P CarneM J Cook
May 9, 2008·Acta Neurologica Scandinavica·U C WieshmannP Eldridge
May 20, 2008·Seizure : the Journal of the British Epilepsy Association·William O TatumFernando L Vale
Apr 25, 2009·Epilepsia·Michael L BellGregory A Worrell
Mar 17, 2010·Epilepsy Research·José F Téllez-ZentenoSamuel Wiebe
Mar 16, 2011·Archives of Neurology·Rafeed AlkawadriPaul C Van Ness
May 28, 2011·Seizure : the Journal of the British Epilepsy Association·Daniel San-juanAlonso-Vanegas Mario
Jun 25, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nealen G LaxpatiRobert E Gross
Sep 23, 2016·JAMA Neurology·Brian Nils LundstromMatt Stead
Jun 24, 2017·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Philippe Ryvlin, Fabienne Picard
Sep 21, 2017·Epilepsy & Behavior : E&B·Imane Samah ChibaneDang Khoa Nguyen
Oct 21, 2017·Journal of Neurosurgery·Panagiotis KerezoudisJamie J Van Gompel

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