Reassessment of enfuvirtide's role in the management of HIV-1 infection

Expert Opinion on Pharmacotherapy
Patricia Marr, Sharon Walmsley

Abstract

The development of new protease inhibitors, new non-nucleoside reverse transcriptase inhibitors and novel therapeutic drug classes has dramatically changed the approach to managing HIV-1 patients with multidrug resistant virus. This has led many clinicians to reevaluate the clinical utility of enfuvirtide. To summarize recent literature on enfuvirtide and to reassess enfuvirtide's role in the management of HIV-1 infection. MEDLINE (1990 to February Week 2 2008) and EMBASE (1990 to 2008 week 8) databases were searched using the following terms: 'enfuvirtide', 'Fuzeon', 'T20', 'HIV fusion inhibitors', and 'HIV entry inhibitor'; limits: English language. Reference lists of articles deemed relevant were hand searched for additional publications. Significant abstracts from recent international HIV conferences were also identified. Enfuvirtide can optimize the response to new combinations of HIV-1 drug regimens in multiresistant patients. Its inclusion as an active agent is effective but use is impacted by its high cost, inconvenient route of administration and cosmetic side-effect profile.

References

May 23, 2001·Antiviral Research·C C LaBrancheS M Hammer
Jun 8, 2001·Annual Review of Biochemistry·D M Eckert, P S Kim
Sep 19, 2002·The Pediatric Infectious Disease Journal·Joseph A ChurchUNKNOWN PACTG P1005 Study Team. Pediatric AIDS Clinical Trials Group
Nov 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jacqueline D ReevesRobert W Doms
Feb 4, 2003·The Journal of Antimicrobial Chemotherapy·Graeme Moyle
Mar 15, 2003·The New England Journal of Medicine·Jacob P LalezariUNKNOWN TORO 1 Study Group
May 30, 2003·The New England Journal of Medicine·Adriano LazzarinUNKNOWN TORO 2 Study Group
May 30, 2003·The New England Journal of Medicine·Karen T Tashima, Charles C J Carpenter
Jun 20, 2003·Nature Reviews. Drug Discovery·Brian L Bray
Jul 23, 2003·Current Medicinal Chemistry·José A Esté
Sep 6, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jacob P LalezariTosca Kinchelow
Nov 15, 2003·Journal of Clinical Pharmacology·Mark Alastair BoydIndravadan H Patel
Dec 16, 2003·The Journal of Infectious Diseases·Sharon WalmsleyJohn Delehanty
Apr 28, 2004·Clinical Therapeutics·Horatio B Fung, Yi Guo
May 1, 2004·AIDS Research and Human Retroviruses·Eva PovedaVincent Soriano
Jun 5, 2004·Clinical Pharmacology and Therapeutics·Xiaoping ZhangIndravadan H Patel
Jun 10, 2004·AIDS Research and Human Retroviruses·Tonie CilliersLynn Morris
Jun 17, 2004·Journal of Clinical Pharmacology·Kiat RuxrungthamIndravadan H Patel
Jul 21, 2004·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·M Christine Jamjian, Ian R McNicholl
Aug 6, 2004·The Pediatric Infectious Disease Journal·Joseph A ChurchUNKNOWN Pediatric AIDS Clinical Trials Group P1005 Study Team
Aug 21, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Calvin J CohenJesse Green
Nov 17, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph A DeSimoneJohn Cohn
Dec 8, 2004·Journal of Virological Methods·Kristel Van LaethemAnne-Mieke Vandamme
Jan 20, 2005·Clinical Pharmacokinetics·Indravadan H PatelNeil Buss
Mar 30, 2005·Expert Opinion on Pharmacotherapy·Adriano Lazzarin
Apr 9, 2005·The Pediatric Infectious Disease Journal·Melisse S Baylor, Rosemary Johann-Liang
May 24, 2005·Drugs·Vicki OldfieldGreg Plosker
Jul 2, 2005·AIDS Research and Human Retroviruses·Eva PovedaVincent Soriano
Oct 18, 2005·AIDS·Raghavan ChinnaduraiFrank Kirchhoff
Nov 11, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Benoit TrottierMiklos P Salgo
Nov 16, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Eva PovedaVincent Soriano
Jan 27, 2006·Antimicrobial Agents and Chemotherapy·Hartmut StockerMichael Kurowski
Feb 9, 2006·The Journal of Antimicrobial Chemotherapy·Verónica BrizVincent Soriano

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Citations

Nov 18, 2009·Sexual Health·Anna C HearpsSuzanne M Crowe
Apr 30, 2009·Molecular Interventions·Catherine S Adamson, Eric O Freed
Dec 24, 2010·British Journal of Clinical Pharmacology·Marco DoniaFerdinando Nicoletti
Dec 23, 2008·The Journal of Biological Chemistry·Changhua JiSurya Sankuratri

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