Reassessment of the polar fraction of Stachys alopecuros (L.) Benth. subsp. divulsa (Ten.) Grande (Lamiaceae) from the Monti Sibillini National Park: A potential source of bioactive compounds

Journal of Intercultural Ethnopharmacology
Alessandro VendittiArmandodoriano Bianco

Abstract

The phytochemical analysis of Stachys alopecuros subsp. divulsa, an endemic Italian species, has been recently reported and has showed the presence of 8-O-acetylharpagide (2), harpagide (3), allobetonicoside (4), and 4¢-O-galactopyranosyl-teuhircoside (5). In this paper, an in deep study of its glycosidic fraction with the aim to widen the knowledge on its secondary metabolites content is reported. Chromatographic techniques were used for the isolation of constituents while spectroscopic and spectrometric techniques were applied for the structures elucidation. Besides the known constituents, all of them reconfirmed, ajugoside (1), reptoside (6) and 6-O-acetyl-ajugol (7) were also identified among the iridoids while the phenolic components resulted to be chlorogenic acid (8), b-arbutin (9), verbascoside (10), and stachysoside A (11), instead. The iridoid pattern of S. alopecuros subsp. divulsa has been expanded with the identification of not previously reported compounds as well as for the phenolic fraction. Except for the reconfirmed verbascoside (10), the other phenolic compounds were recognized for the first time in the studied species. The complete NMR assignment of compound (1) by means of bidimensional techniques is report...Continue Reading

Citations

Oct 24, 2017·Natural Product Research·Claudio FrezzaMauro Serafini
Apr 14, 2020·Natural Product Research·Ayşe GökmenHasan Kırmızıbekmez
Dec 11, 2020·Natural Product Research·Antim K MauryaVijai K Agnihotri
Oct 31, 2020·Fitoterapia·Claudio FrezzaMauro Serafini

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Datasets Mentioned

BETA
SAD-30062012

Methods Mentioned

BETA
NMR

Software Mentioned

MassLynx

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