Rebamipide ameliorates radiation-induced intestinal injury in a mouse model

Toxicology and Applied Pharmacology
Sehwan ShimSunhoo Park

Abstract

Radiation-induced enteritis is a major side effect in cancer patients undergoing abdominopelvic radiotherapy. Radiation exposure produces an uncontrolled inflammatory cascade and epithelial cell loss leading to impaired epithelial barrier function. The goal of this study was to determine the effect of rebamipide on regeneration of the intestinal epithelia after radiation injury. The abdomens of C57BL/6 mice were exposed to 13Gy of irradiation (IR) and then the mice were treated with rebamipide. Upon IR, intestinal epithelia were destroyed structurally at the microscopic level and bacterial translocation was increased. The intestinal damage reached a maximum level on day 6 post-IR and intestinal regeneration occurred thereafter. We found that rebamipide significantly ameliorated radiation-induced intestinal injury. In mice treated with rebamipide after IR, intestinal barrier function recovered and expression of the tight junction components of the intestinal barrier were upregulated. Rebamipide administration reduced radiation-induced intestinal mucosal injury. The levels of proinflammatory cytokines and matrix metallopeptidase 9 (MMP9) were significantly reduced upon rebamipide administration. Intestinal cell proliferation and ...Continue Reading

Citations

Oct 20, 2017·Journal of Gastroenterology and Hepatology·Hyosun JangSehwan Shim
Jul 1, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao-Min ZhangLing-Ling Zhu
Dec 6, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Seo-Young KwakHyosun Jang
Nov 22, 2020·International Immunopharmacology·Ning XuZhenhai Yu

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