Rebamipide does not interfere with the antitumor effect of radiotherapy or chemotherapy in human oral tumor-bearing nude mice

Journal of Pharmacological Sciences
Masafumi ShibamoriKazushi Sakurai

Abstract

Recent studies have shown that rebamipide, which suppresses reactive oxygen species, prevents chemoradiotherapy-induced oral mucositis in patients with head and neck cancers. However, anticancer action of radiotherapy and chemotherapy is believed to be partially associated with generation of reactive oxygen species. The aim of this study was to determine whether rebamipide interferes with the antitumor action of radiotherapy and chemotherapy. The effect of rebamipide on tumor cell growth was investigated using a human oral squamous carcinoma cell line, HSC-2, in vitro and in vivo. Rebamipide showed no significant effect on cell or tumor growth in HSC-2 tumor-bearing nude mice. Influences of rebamipide on the antitumor action of radiotherapy and of chemotherapy with cisplatin or docetaxel were investigated using the same animal model. In radiotherapy, the tumor was treated with 2.5 Gy of X-rays for 5 days, and rebamipide (300 mg/kg p.o.) was administered during irradiation periods. In chemotherapy, tumor-bearing mice were treated once with cisplatin (8 mg/kg, i.v.) or docetaxel (15 mg/kg i.v.) and rebamipide (300 mg/kg p.o.) was administered for 5 days following the antitumor drug treatment. Rebamipide did not interfere with the...Continue Reading

References

Oct 6, 1987·European Journal of Pharmacology·K YamasakiS Morita
Jun 22, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S Y SaadM O Al-Sohaibani
Apr 8, 2003·Scandinavian Journal of Gastroenterology·A UdagawaY Murawaki
Apr 2, 2004·Nature Reviews. Cancer·Stephen T Sonis
Apr 27, 2004·Cancer·Stephen T SonisUNKNOWN International Society for Oral Oncology
Apr 19, 2005·The International Journal of Biochemistry & Cell Biology·Ji Hoon YuKyung Hwan Kim
Jul 5, 2005·Biochemical and Biophysical Research Communications·A TarnawskiE C Chu
Dec 24, 2005·Apoptosis : an International Journal on Programmed Cell Death·C Di PietroM Purrello
Dec 16, 2006·Digestive Diseases and Sciences·Tetsuya TanigawaAndrzej S Tarnawski
Jun 10, 2010·Expert Review of Gastroenterology & Hepatology·Yuji Naito, Toshikazu Yoshikawa
Jul 8, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jung-Yoon ChoeSeong-Kyu Kim
Jun 27, 2012·Biochemical and Biophysical Research Communications·Nobutake YamamichiKazuhiko Koike
Sep 14, 2012·CA: a Cancer Journal for Clinicians·Joel B EpsteinEllie Maghami
Jul 10, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierre BlanchardUNKNOWN Meta-Analysis of Chemotherapy in Head and Neck Cancer, Induction Project, Collaborative Group
Aug 1, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Siri Beier JensenUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Sep 26, 2013·The Journal of Pharmacology and Experimental Therapeutics·Takako NakashimaTatsuhiro Ishida
Apr 4, 2014·Biological & Pharmaceutical Bulletin·Takako NakashimaTatsuhiro Ishida
Jan 27, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Hironobu TsukamotoTakashi Joh

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Citations

Aug 30, 2018·Journal of Immunology Research·Dan LuoZi-Ling Wang
Feb 17, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Takako NakashimaKazushi Sakurai

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