Rebaudioside A potently stimulates insulin secretion from isolated mouse islets: studies on the dose-, glucose-, and calcium-dependency

Metabolism: Clinical and Experimental
R AbudulaKjeld Hermansen

Abstract

Extracts of leaves of the plant Stevia rebaudiana Bertoni (SrB), have been used for many years in traditional treatment of diabetes in South America. Stevia leaves contain diterpene glycosides, stevioside and rebaudioside A being the most abundant. Recently, it was demonstrated that stevioside stimulates the insulin secretion both in vitro and in vivo. Subsequently, we wanted to elucidate the influence of rebaudioside A on the insulin release from mouse islets using static incubations, as well as perifusion experiments. Rebaudioside A (10(-16) to 10(-6) mol/L) dose-dependently stimulated the insulin secretion in the presence of 16.7 mmol/L glucose (P < .05). The stimulation of insulin release occurs at a concentration of 10(-14) mol/L rebaudioside A, and maximal insulin response was obtained at 10(-10) mol/L (P < .01). Rebaudioside A stimulates insulin secretion in a glucose-dependent manner (3.3 to 16.7 mmol/L) and only potentiated insulin secretion at glucose > 6.6 mmol/L. The effect of rebaudioside A is critically dependent on the presence of extracellular Ca2+, ie, rebaudioside A-induced insulin stimulation at high glucose disappears in the absence of extracellular Ca2+. In conclusion, rebaudioside A possesses insulinotropi...Continue Reading

Citations

Jun 12, 2008·European Journal of Drug Metabolism and Pharmacokinetics·Aleksandar RaskovićDjendji Siladji
Jun 9, 2012·The Journal of Clinical Endocrinology and Metabolism·Rebecca J Brown, Kristina I Rother
Mar 1, 2012·Journal of Pharmacy & Bioallied Sciences·Vasim KhanK K Pillai
Nov 13, 2008·Pharmacology & Therapeutics·Varanuj Chatsudthipong, Chatchai Muanprasat
Feb 23, 2008·International Journal of Toxicology·Andrey I Nikiforov, Alex K Eapen
Jun 23, 2018·Journal of Complementary & Integrative Medicine·Imran MahmudMd Khirul Islam
Oct 3, 2019·Biomolecules·Bahare SalehiJavad Sharifi-Rad
Jul 12, 2017·BioMed Research International·Livier Mireya Sánchez-AcevesLeobardo Manuel Gómez-Oliván
Feb 10, 2018·Journal of the American College of Nutrition·Noor Rohmah Mayasari Probosuseno
Jun 2, 2018·International Journal of Endocrinology·Silvano PiovanCecília Edna Mareze-Costa
Aug 9, 2020·Frontiers in Endocrinology·Eleonora MoriconiMassimiliano Caprio

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