Rebooting Human Immunology

Annual Review of Immunology
Mark M Davis, Petter Brodin

Abstract

Recent progress in both conceptual and technological approaches to human immunology have rejuvenated a field that has long been in the shadow of the inbred mouse model. This is a healthy development both for the clinical relevance of immunology and for the fact that it is a way to gain access to the wealth of phenomenology in the many human diseases that involve the immune system. This is where we are likely to discover new immunological mechanisms and principals, especially those involving genetic heterogeneity or environmental influences that are difficult to model effectively in inbred mice. We also suggest that there are likely to be novel immunological mechanisms in long-lived, less fecund mammals such as human beings since they must remain healthy far longer than short-lived rodents in order for the species to survive.

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Citations

Nov 6, 2018·The FEBS Journal·Petter Brodin
Jan 17, 2019·Annual Review of Immunology·Kevin BasslerJoachim L Schultze
May 7, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Axel R SchulzHenrik E Mei
Jun 21, 2019·The Journal of Experimental Medicine·Hye Kyung LimShen-Ying Zhang
Oct 17, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Sonia GavassoAttila Tárnok
Jan 30, 2020·The New England Journal of Medicine·Scott B DrutmanJean-Laurent Casanova
Feb 11, 2020·Human Genetics·Petter Brodin
Oct 3, 2019·Proceedings. Biological Sciences·Mauricio SeguelVanessa O Ezenwa
Jun 27, 2019·The Journal of Experimental Medicine·Anne Puel, Jean-Laurent Casanova
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Aug 9, 2019·Nature·Naresha SaligramaMark M Davis
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Jun 19, 2021·Cell·Bethany M HenrickPetter Brodin
Aug 31, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Emanuele CozziUNKNOWN for ESOT Workstream 1 of the TLJ (Transplantation Learning Journey) Project

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Methods Mentioned

BETA
PCR
GLIPH
fluorescence-activated cell sorting
exome-sequencing
transgenics
transgenic

Software Mentioned

GEO
ImmPort
ImmuneSpace
GLIPH
Pipeline

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