Rebound in the incidence of pneumococcal meningitis in northern France: effect of serotype replacement

Acta Paediatrica
C AlexandreA Martinot

Abstract

To determine whether the recent emergence of nonvaccine pneumococcal serotypes has affected the incidence of pneumococcal meningitis in children a few years after the introduction of the heptavalent pneumococcal conjugate vaccine. We conducted a multicentre retrospective cohort study from 2005 to 2008 in all hospitals with paediatric units in northern France. It included all patients < 18 years of age who were admitted for laboratory-confirmed pneumococcal meningitis during the study period. Data were collected from medical files and laboratory records at each hospital and compared with the regional hospital discharge codes. We assessed global and age-specific incidence rates of pneumococcal meningitis from 2005 through 2008, compared them with those from the prevaccine era (2000-2002) and evaluated pneumococcal serotypes. In all, 41 cases were found during the study period. The incidence rate of pneumococcal meningitis varied from 0.8/100,000 children < 18 years in 2005 to 1.8/100,000 children in 2008 (2.2-fold increase, p = 0.06); and from 1.8 to 11.9/100,000 children < 2 years (6.5-fold increase, p = 0.004). This increase was caused by nonvaccine pneumococcal serotypes. The incidence of pneumococcal meningitis in infants has...Continue Reading

References

Dec 31, 2002·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·D Floret
Apr 23, 2003·Vaccine·Katherine L O'Brien, Ron Dagan
Jul 6, 2004·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·S BlackP Reinert
May 24, 2005·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·E BingenUNKNOWN Groupe des pédiatres et microbiologistes de l'Observatoire national des méningites
Dec 8, 2005·European Journal of Pediatrics·Juan Casado-FloresUNKNOWN Spanish Pneumococcal Meningitis Study Group
Feb 9, 2007·Vaccine·Kimberly J Center
Jul 13, 2007·Archives of Disease in Childhood·F DubosUNKNOWN Hospital Network for Evaluating the Management of Common Childhood Diseases
Dec 7, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E BingenUNKNOWN Bacterial Meningitis Study Group
Apr 15, 2008·Emergency Medicine Clinics of North America·Sharon E Mace
Sep 3, 2008·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·A LepoutreDaniel Lévy-Bruhl
Oct 11, 2008·The Pediatric Infectious Disease Journal·Juan Casado-FloresCristina Mendez
Nov 22, 2008·The Lancet Infectious Diseases·Ron Dagan, Keith P Klugman
Jan 16, 2009·The New England Journal of Medicine·Heather E HsuLee H Harrison
Apr 28, 2009·FEMS Microbiology Reviews·Ola Johnsborg, Leiv Sigve Håvarstein
Nov 21, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·P BidetE Bingen
Jul 28, 2010·The Pediatric Infectious Disease Journal·Noga Givon-LaviRon Dagan

❮ Previous
Next ❯

Citations

May 26, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B DunaisC Pradier
Sep 13, 2011·PLoS Neglected Tropical Diseases·Rolando PajonDan M Granoff
Oct 6, 2014·Nature Chemical Biology·Marco CavallariGennaro De Libero
May 12, 2015·Expert Review of Anti-infective Therapy·Hannah C McNeilStuart C Clarke
Jun 13, 2015·Scientific Reports·Matthieu Domenech de CellèsDidier Guillemot
Feb 8, 2020·The Pediatric Infectious Disease Journal·Reshmi Mukerji, David E Briles
Mar 26, 2014·Paediatrics & Child Health·Nicole Le Saux, UNKNOWN Canadian Paediatric Society, Infectious Diseases and Immunization Committee
Mar 7, 2020·ACS Infectious Diseases·Emma Roig-MolinaBeatriz Maestro
Mar 30, 2021·Russian Journal of Bioorganic Chemistry·M L GeningN E Nifantiev
Jun 8, 2021·The Pediatric Infectious Disease Journal·Emilie CoronasUNKNOWN Hospital Network for Evaluating the Management of Common Childhood Diseases
Apr 16, 2011·Lancet·Daniel M WeinbergerMarc Lipsitch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.