Rebound or Entrainment? The Influence of Alternating Current Stimulation on Individual Alpha

Frontiers in Human Neuroscience
Linus HaberboschStephan A Brandt

Abstract

Alternating current stimulation (ACS) is an established means to manipulate intrinsic cortical oscillations. While working towards clinical impact, ACS mechanisms of action remain unclear. For ACS's well-documented influence on occipital alpha, hypotheses include neuronal entrainment as well as rebound phenomena. As a retinal origin is also discussed, we employed a novel form of ACS with the advantage that it specifically targets occipital alpha-oscillations via retinofugal pathways retinofugal ACS (rACS). We aimed to confirm alpha-enhancement outlasting the duration of stimulation with 10 Hz rACS. To distinguish entrainment from rebound effects, we investigated the correlation between alpha peak frequency change and alpha-enhancement strength. We quantified the alpha band power before and after 10 Hz rACS in 15 healthy subjects. Alpha power enhancement and alpha peak frequency change were assessed over the occipital electrodes and compared to sham stimulation. RACS significantly enhanced occipital alpha power in comparison to sham stimulation (p < 0.05). Alpha peak frequency changed by a mean 0.02 Hz (± 0.04). A greater change in alpha peak frequency did not correlate with greater effects on alpha power. Our findings show an a...Continue Reading

References

Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C M Gray, W Singer
Jan 1, 1984·The American Journal of Physiology·G B Ermentrout, J Rinzel
Jan 1, 1982·Journal of Mathematical Biology·F C Hoppensteadt, J P Keener
Dec 1, 1993·The International Journal of Neuroscience·H SakamotoK Shinosaki
Jan 1, 1993·Biological cybernetics·D Somers, N Kopell
Sep 29, 1998·The European Journal of Neuroscience·G Rager, W Singer
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·F GrenierM Steriade
Nov 4, 1996·Physical Review Letters·B J GluckmanS J Schiff
Apr 21, 1999·Brain Research. Brain Research Reviews·W Klimesch
Mar 26, 2003·The European Journal of Neuroscience·Wolfgang KlimeschChristian Gerloff
May 22, 2003·Trends in Cognitive Sciences·Rufin VanRullen, Christof Koch
Jan 1, 1958·Archiv für Psychiatrie und Nervenkrankheiten, vereinigt mit Zeitschrift für die gesamte Neurologie und Psychiatrie·A GRUTZNERG BAUMGARTNER
Jun 1, 1962·Experimental Neurology·O D CREUTZFELDTH KAPP
Jan 28, 1955·The Journal of Physiology·G S BRINDLEY
Apr 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hartwig R SiebnerJohn C Rothwell
Jun 26, 2004·Science·György Buzsáki, Andreas Draguhn
Dec 17, 2004·Physical Review Letters·M C CrossJ L Rogers
May 14, 2005·Applied Psychophysiology and Biofeedback·Simon HanslmayrWolfgang Klimesch
Aug 3, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Stuart W Hughes, Vincenzo Crunelli
Aug 5, 2006·Brain Research Reviews·Wolfgang KlimeschSimon Hanslmayr
Nov 7, 2006·Nature·Lisa MarshallJan Born
Nov 15, 2006·Current Opinion in Neurology·Penelope Talelli, John Rothwell
Jun 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Eilon D KirsonYoram Palti
Jun 9, 2007·Human Brain Mapping·Debora BrignaniCarlo Miniussi
May 20, 2008·Journal of Vision·Xin HuangMichael A Paradiso
Nov 26, 2008·Current Biology : CB·Ryota KanaiWalter Paulus
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kyle E MathewsonTony Ro
Mar 17, 2009·Trends in Cognitive Sciences·Gregor Thut, Carlo Miniussi
Jun 10, 2009·Frontiers in Integrative Neuroscience·Caspar M Schwiedrzik
Oct 6, 2009·Current Biology : CB·Alek PogosyanPeter Brown
Dec 31, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Soroush ZaghiFelipe Fregni
Feb 26, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Walter Paulus
Mar 2, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Dennis J L G Schutter, Ruud Hortensius
Apr 13, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ryota KanaiVincent Walsh
Jul 14, 2010·Neuron·Flavio Fröhlich, David A McCormick

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Citations

Aug 24, 2019·Frontiers in Neuroscience·Linus HaberboschSein Schmidt
Oct 23, 2020·PLoS Biology·Mircea van der Plas, Simon Hanslmayr
Oct 26, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Mircea van der PlasSimon Hanslmayr
Jul 27, 2021·Frontiers in Human Neuroscience·Mária Orendáčová, Eugen Kvašňák
Sep 19, 2021·Scientific Reports·Yong-Jun LinMarisa Carrasco

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Software Mentioned

GraphPad Prism
NextWave
SPSS Statistics
FieldTrip
GraphPad
MATLAB

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