PMID: 7022448Jun 1, 1981Paper

recA protein of Escherichia coli promotes branch migration, a kinetically distinct phase of DNA strand exchange

Proceedings of the National Academy of Sciences of the United States of America
M M Cox, I R Lehman

Abstract

The recA protein of Escherichia coli promotes the complete exchange of strands between full-length linear duplex and single-stranded circular DNA molecules of bacteriophage phi X-174, converting more than 50% of the single-stranded DNA into heteroduplex replicative form II-like structures. Kinetically, the reaction can be divided into two phases, formation of short heteroduplex regions (D loops) and extension of the D loops via branch migration. recA protein participates directly in both phases. D loops are formed efficiently in the presence of ATP or the nonhydrolyzable ATP analog adenosine 5'-[gamma-thio]triphosphate, whereas D-loop extension requires continuous ATP hydrolysis. Complete strand exchange requires a stoichiometric amount of recA protein and is strongly stimulated by the single-stranded-DNA-binding protein of E. coli.

References

Jan 1, 1978·Annual Review of Biochemistry·C M Radding
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T ShibataC M Radding
Jan 1, 1979·Cold Spring Harbor Symposia on Quantitative Biology·T OgawaH Ogawa
Jan 1, 1979·Cold Spring Harbor Symposia on Quantitative Biology·J W RobertsE M Phizicky
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T ShibataC M Radding
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G M WeinstockI R Lehman
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·K McEnteeI R Lehman
Jun 5, 1979·Journal of Molecular Biology·E J Sodergren, M S Fox
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·W K Holloman, C M Radding
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·K McEnteeW Epstein
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·B J ThompsonR C Warner
Jan 1, 1973·Annual Review of Genetics·A J Clark
Jan 1, 1974·Annual Review of Microbiology·R D Hotchkiss
Aug 28, 1971·Journal of Molecular Biology·T R Broker, I R Lehman
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T HoriiH Ogawa
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·K McEnteeI R Lehman
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A SancarW D Rupp
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P A Simpson, J A Spudich
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S C WestP Howard-Flanders
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T ShibataC M Radding
Nov 1, 1980·Cell·C DasGuptaC M Radding

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Citations

Nov 9, 2000·Archives of Biochemistry and Biophysics·S E Steffen, F R Bryant
May 22, 2001·Archives of Biochemistry and Biophysics·S E Steffen, F R Bryant
Aug 31, 2001·Biochemical and Biophysical Research Communications·M D BergerS F Singleton
Jan 1, 1983·Molecular & General Genetics : MGG·A Cohen, A Laban
Jan 1, 1983·Molecular & General Genetics : MGG·R G Lloyd, A Thomas
Jan 1, 1983·Molecular & General Genetics : MGG·R G LloydC Prescott
Jan 1, 1984·Molecular & General Genetics : MGG·R G Lloyd, A Thomas
Jan 1, 1982·Molecular & General Genetics : MGG·S C WestP Howard-Flanders
Sep 1, 1988·Molecular & General Genetics : MGG·J R Simon, P D Moore
Feb 1, 1990·Molecular & General Genetics : MGG·E Akaboshi, P Howard-Flanders
Jan 1, 1982·Molecular & General Genetics : MGG·S C WestP Howard-Flanders
Feb 20, 1989·Journal of Molecular Biology·J E Lindsley, M M Cox
Feb 19, 1996·Mutation Research·R JessbergerB Kemper
Feb 1, 1991·Biochimie·A K Eggleston, S C Kowalczykowski
Nov 30, 1988·Biochemical and Biophysical Research Communications·M Amaratunga, A S Benight
Dec 4, 2002·Protein Expression and Purification·Scott F SingletonAlberto I Roca
Jan 18, 2007·Nature Reviews. Molecular Cell Biology·Michael M Cox
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Matthew J RossiAlexander V Mazin
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M M Cox, I R Lehman
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R KahnC M Radding
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·Z Livneh, I R Lehman
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C DasGupta, C M Radding
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A M WuC M Radding
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S A Chow, C M Radding
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·F R Bryant, I R Lehman
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S RauthR Kucherlapati
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B RigasS M Weissman
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J C Register, J Griffith
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S C KowalczykowskiR A Krupp
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B B Konforti, R W Davis

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