Recent advancements in mesoporous silica nanoparticles towards therapeutic applications for cancer

Acta Biomaterialia
Tingting LiYiyao Liu

Abstract

Recently, drug delivery systems based on nanotechnology have received great attention in cancer therapeutics and diagnostics since they can not only improve the treatment efficacy but also reduce the side effects. Among them, mesoporous silica nanoparticles (MSNs) with large surface area, high pore volume, tunable pore size, abundant surface chemistry, and acceptable biocompatibility exhibit unique advantages and are considered as promising candidates for cancer diagnosis and therapy. In this review, we update the recent progress on MSN-based systems for cancer treatment purposes. We also discuss the drug loading mechanism of MSNs, stimuli-responsive drug release, and surface modification strategies for improving biocompatibility, and targeting functionalities. STATEMENT OF SIGNIFICANCE: The development of MSN-based delivery systems that can be used in both diagnosis and treatment of cancer has attracted tremendous interest in the past decade. MSN-based delivery systems can improve therapeutic efficacy and reduce cytotoxicity to normal tissue. To further improve the in vivo properties of MSNs and potential translation to the clinics, it is critical to design MSNs with appropriate surface engineering and desirable cancer targeti...Continue Reading

Citations

Feb 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hao LiJean-Olivier Durand
Aug 14, 2020·Pharmaceutics·Twana Mohammed M WaysVitaliy V Khutoryanskiy
May 16, 2020·Frontiers in Bioengineering and Biotechnology·Tingting LiYiyao Liu
May 6, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Roy C H WongPui-Chi Lo
Jun 13, 2020·Frontiers in Bioengineering and Biotechnology·Ivan GuryanovRawil Fakhrullin
May 6, 2020·International Journal of Nanomedicine·Ying DongYanjun Jiang
Jun 12, 2020·Pharmaceutics·Sugata Barui, Valentina Cauda
Dec 16, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Samere AbolghasemzadeMona Navaei-Nigjeh
Jan 17, 2021·Biomedicines·Chihiro MochizukiMichihiro Nakamura
Mar 13, 2021·Frontiers in Chemistry·Ajita JindalAftab Alam
May 1, 2021·Polymers·Nikolaos TheodorakisConstantinos Tsitsilianis
Aug 7, 2021·Macromolecular Bioscience·Wenzhen DuPeng Zhang
Oct 1, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Xuebin MaJingcheng Hao
Oct 11, 2021·International Journal of Pharmaceutics·Dnyaneshwar KalyaneRakesh Kumar Tekade
Nov 6, 2020·International Journal of Pharmaceutics·Shweta ParohaPrashant Kesharwani

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