Recent advancements in the management of retinoblastoma and uveal melanoma

F1000Research
Amy C Schefler, Ryan S Kim

Abstract

Retinoblastoma and uveal melanoma are the most common intraocular malignancies observed in pediatric and adult populations, respectively. For retinoblastoma, intra-arterial chemotherapy has dramatically improved treatment outcomes and eye salvage rates compared with traditional salvage rates of systemic chemotherapy and external beam radiation therapy. Intravitreal injections of chemotherapy have also demonstrated excellent efficacy for vitreous seeds. Uveal melanoma, on the other hand, is treated predominantly with iodine-125 plaque brachytherapy or with proton beam therapy. Major strides in uveal melanoma genomics have been made since the early 2000s, allowing ocular oncologists to better understand the metastatic risks of the tumor on the basis of specific genetic signatures. Loss-of-function mutations of the BAP1 gene are associated with the highest metastatic risk, whereas gain-of-function mutations of SF3B1 and EIF1AX often confer a better prognosis. Expression of a cancer-testis antigen called PRAME (preferentially expressed antigen in melanoma) has been shown to increase metastatic risks in both low-risk and high-risk melanomas. New therapeutic approaches, including molecular therapies and nanoparticle phototherapy, are...Continue Reading

References

Nov 21, 1990·Journal of the National Cancer Institute·G PrescherR Becher
Nov 1, 1990·Medical Physics·M A AstrahanZ Petrovich
Mar 1, 1990·International Journal of Radiation Oncology, Biology, Physics·M A AstrahanZ Petrovich
Nov 1, 1996·Archives of Ophthalmology·J E KingstonP N Plowman
Oct 6, 1997·International Journal of Radiation Oncology, Biology, Physics·M A AstrahanZ Petrovich
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C L ShieldsA T Meadows
Jul 27, 2001·Archives of Ophthalmology·M Diener-WestUNKNOWN Collaborative Ocular Melanoma Study Group
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Subir NagUNKNOWN American Brachytherapy Society
May 17, 2003·Ophthalmology·Arun D Singh, Allan Topham
Oct 28, 2003·Investigative Ophthalmology & Visual Science·Emma KujalaTero Kivelä
Apr 27, 2004·International Journal of Clinical Oncology·Takashi YamaneMakoto Mohri
Dec 8, 2004·Retina·David H Abramson, Amy C Schefler
Jan 15, 2005·Cancer·Colleen C McLaughlinVivien W Chen
Mar 15, 2005·Ophthalmology Clinics of North America·A Linn Murphree
Sep 26, 2006·Ophthalmology·Carol L ShieldsJerry A Shields
Feb 3, 2009·Investigative Ophthalmology & Visual Science·Bertil DamatoSarah E Coupland
Nov 13, 2009·Pediatric Blood & Cancer·Ira J DunkelDavid H Abramson
Jul 14, 2010·Archives of Ophthalmology·Ivana K KimEvangelos S Gragoudas
Nov 6, 2010·Science·J William HarbourAnne M Bowcock
Feb 16, 2011·Archives of Ophthalmology·Y Pierre GobinDavid H Abramson
Jun 28, 2011·Ophthalmology·Arun D SinghAllan K Topham
Nov 1, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Solange LandrevilleJ William Harbour
Sep 15, 2012·Investigative Ophthalmology & Visual Science·Anthony B DanielsIvana K Kim
Oct 9, 2012·International Journal of Radiation Oncology, Biology, Physics·Zhen WangM Hassan Murad
Oct 10, 2012·Archives of Ophthalmology·Fariba Ghassemi, Carol L Shields
Jul 6, 2013·Arquivos brasileiros de oftalmologia·James Jay AugsburgerNikolaos Trichopoulos

❮ Previous
Next ❯

Citations

Sep 9, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Santosh Kumar PatnaikThirumurthy Velpandian
Nov 25, 2018·Archives of Pharmacal Research·Dong Hyun JoJeong Hun Kim
Jun 9, 2020·Seminars in Ophthalmology·Mehenaz Hanbazazh, Thaddeus P Dryja
Jun 27, 2020·AJNR. American Journal of Neuroradiology·A SweidP Jabbour
Jan 20, 2019·Current Topics in Medicinal Chemistry·Kamakshi DanduCh Mohan Rao
Apr 6, 2021·Pediatric Blood & Cancer·Samir PatelMatthew J Krasin
May 1, 2021·The Medical Clinics of North America·Basil K Williams, Maura Di Nicola
May 7, 2021·Oncotarget·Nathalie Allaman-Pillet, Daniel F Schorderet
Sep 4, 2021·Experimental Eye Research·Vanessa MendonçaHéctor N Seuánez

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
biopsies
biopsy

Clinical Trials Mentioned

NCT02223819
NCT02068586
NCT01979523
NCT01585194
NCT02570308
NCT02359851
NCT02273219
NCT01473004
NCT02678572
NCT01814046

Software Mentioned

Plaque Simulation

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Eva BiewaldN Bornfeld
American Journal of Ophthalmology
Aline I RiechardtAntonia M Joussen
Archives of Ophthalmology
E S Gragoudas
International Journal of Radiation Oncology, Biology, Physics
Bradford A PerezDavid G Kirsch
© 2022 Meta ULC. All rights reserved