Recent advances and novel agents for gastrointestinal stromal tumor (GIST).

Journal of Hematology & Oncology
Gurpreet LambaDelong Liu

Abstract

The discovery of CD117 mutation in almost all gastrointestinal stromal tumors (GISTs) marked a milestone. Other spindle cell neoplasms arising from the GI tract including lipoma, schwannoma, hemangioma, leiomyoma, and leiomyosarcoma are typically CD117-negative. GIST research and clinical care now represent a paradigm of translating discoveries in the molecular pathogenesis of cancer into highly effective targeted therapies that selectively inhibit etiologic "driver" pathways, leading to dramatically improved clinical outcomes. A series of investigations and trials are underway to develop novel and effective ways to treat patients with GIST. In this review, we discuss the highlights of recent advances and novel agents for GIST therapy.

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Citations

Jul 9, 2013·Journal of Medical Genetics·Margherita NanniniMaria A Pantaleo
Aug 21, 2013·Journal of Hematology & Oncology·Akintunde AkinleyeDelong Liu
Nov 23, 2013·Journal of Hematology & Oncology·Akintunde AkinleyeDelong Liu
Dec 7, 2013·Journal of Hematology & Oncology·Muhammad FurqanDelong Liu
Nov 21, 2013·Biomarker Research·Chung-Tsen HsuehHong Wang
Dec 6, 2012·Experimental Hematology & Oncology·Gurpreet LambaDelong Liu
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May 20, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kwaku Appiah-KubiYongchang Chen
Feb 1, 2014·Clinical Kidney Journal·Norbert Lameire

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Methods Mentioned

BETA
genotyping
transfection
biopsies

Clinical Trials Mentioned

NCT00812240
NCT01243346

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