Recent Advances and Perspectives in Cancer Drug Design

Anais Da Academia Brasileira De Ciências
Luma G MagalhaesAdriano D Andricopulo

Abstract

Cancer is one of the leading causes of death worldwide. With the increase in life expectancy, the number of cancer cases has reached unprecedented levels. In this scenario, the pharmaceutical industry has made significant investments in this therapeutic area. Despite these efforts, cancer drug research remains a remarkably challenging field, and therapeutic innovations have not yet achieved expected clinical results. However, the physiopathology of the disease is now better understood, and the discovery of novel molecular targets has refreshed the expectations of developing improved treatments. Several noteworthy advances have been made, among which the development of targeted therapies is the most significant. Monoclonal antibodies and antibody-small molecule conjugates have emerged as a worthwhile approach to improve drug selectivity and reduce adverse effects, which are the main challenges in cancer drug discovery. This review will examine the current panorama of drug research and development (R&D) with emphasis on some of the major advances brought to clinical trials and to the market in the past five years. Breakthrough discoveries will be highlighted along with the medicinal chemistry strategies used throughout the discov...Continue Reading

References

Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B N AmesT M Hagen
Jul 17, 1998·Medicinal Research Reviews·A JordanA T McGown
Dec 2, 2000·Journal of Medicinal Chemistry·M BarvianE Zhang
Feb 8, 2002·Cell·Ashok R Venkitaraman
Jun 11, 2004·Annual Review of Biochemistry·Aziz SancarStuart Linn
Apr 2, 2005·Journal of Medicinal Chemistry·Peter L ToogoodDavid W Fry
Apr 20, 2005·Bioorganic & Medicinal Chemistry Letters·Vincent M LohAlan J Whittle
Jun 2, 2005·Nature Reviews. Cancer·Gillian M TozerBruce C Baguley
Jun 23, 2006·Journal of Medicinal Chemistry·Heshu Lu, Ursula Schulze-Gahmen
Jun 29, 2006·British Journal of Haematology·Denis R Miller
Feb 27, 2007·The American Journal of Pathology·James E TalmadgeAvraham Raz
Aug 21, 2007·Accounts of Chemical Research·Ravi V J Chari
Feb 22, 2008·Current Medicinal Chemistry·A Petrelli, S Giordano
Apr 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert K Oldham, Robert O Dillman
Aug 5, 2008·Drug Discovery Today·Matteo Colombo, Ilaria Peretto
Nov 18, 2008·Cancer Research·Gail D Lewis PhillipsMark X Sliwkowski
Dec 3, 2008·Disease Models & Mechanisms·Ann Richmond, Yingjun Su
Jan 30, 2009·The New England Journal of Medicine·Peter B Bach
Jun 2, 2010·Nature Reviews. Drug Discovery·Saurabh Aggarwal
Oct 5, 2010·Nature Reviews. Drug Discovery·Charles Dumontet, Mary Ann Jordan
Feb 22, 2012·Nature Biotechnology·Elisabet WahlbergJohan Weigelt
Feb 22, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Colby M ChapmanAdrian Wiestner
Nov 3, 2012·Cancer Research·Junko MuraiYves Pommier
Apr 8, 2014·Cancer Discovery·Carlo ToniattiGiulio Draetta
Jun 27, 2014·Journal of Medicinal Chemistry·John M Lambert, Ravi V J Chari
Jul 19, 2014·Nature Reviews. Drug Discovery·John G MoffatDavid Bailey
Aug 31, 2014·Drug Discovery Today·Michael S Kinch
Oct 18, 2014·Nature Reviews. Drug Discovery·Adrienne D CoxChanning J Der
Jan 31, 2015·Nature Reviews. Drug Discovery·Uzma AsgharErik S Knudsen
Jun 16, 2015·Nature Chemical Biology·Daniel P BondesonCraig M Crews
Feb 10, 2016·Nature Reviews. Clinical Oncology·Richard Sullivan, Ajay Aggarwal
Mar 2, 2016·Journal of Health Economics·Joseph A DiMasiRonald W Hansen
Apr 7, 2016·Nature Reviews. Drug Discovery·Duncan E ScottJohn Skidmore
Apr 23, 2016·Cell·Sai Krishna Athuluri-DivakarE Premkumar Reddy
Aug 9, 2016·Molecular Cancer Therapeutics·Ping ChenBrion W Murray

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Expert Opinion on Drug Discovery
Leonardo G FerreiraAdriano D Andricopulo
Bioorganic & Medicinal Chemistry Letters
Timothy B Durham, Maria-Jesus Blanco
Expert Opinion on Therapeutic Patents
Saúl Abenhamar NavarroHouria Boulaiz
Nature Reviews. Clinical Oncology
Anastasios Stathis, Malcolm J Moore
© 2022 Meta ULC. All rights reserved