Recent advances and perspectives on coated alginate microspheres for modified drug delivery

Expert Opinion on Drug Delivery
Pietro MatricardiFranco Alhaique

Abstract

Alginate microspheres represent a useful tool for modified drug delivery. Their preparation is quite easy and is usually based on the gelling properties of the polysaccharide in the presence of divalent ions; nevertheless, microparticles prepared only with calcium alginate show several problems, mainly related to the mechanical stability and to the release that, in most cases, is too fast. To overcome such inconveniences, polymer-coated alginate microspheres and/or appropriately interpenetrating polymer network (semi-IPNs and IPNs) structures formed with alginate and other macromolecules were developed. This article reports a synthetic overview on the most recent searches carried out on coated alginate microspheres. After a section focused on the microsphere preparation, this article is divided into several main topics related to the specific polymer that was used as a coating material to provide a rationale in reporting literature data. In the last section, the advantages and disadvantages of the various approaches are discussed and the authors' opinion on perspectives for further studies and novel applications of coated alginate microspheres are reported. Ca(2+)-alginate microparticles could experience a new era if scientists...Continue Reading

References

Apr 27, 1999·The Journal of Pharmacy and Pharmacology·P Liu, T R Krishnan
Jun 6, 2000·Advanced Drug Delivery Reviews·S Wee, W R Gombotz
Jan 5, 2002·Advanced Drug Delivery Reviews·Akihiko Kikuchi, Teruo Okano
Apr 12, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rinat M IskakovTeruo Okano
Jul 24, 2002·Pharmaceutical Research·María González FerreiroRoland Bodmeier
Aug 2, 2002·Drug Development and Industrial Pharmacy·Hanne Hjorth Tønnesen, Jan Karlsen
Dec 18, 2004·Biomaterials·Shinji SugiuraMitsutoshi Nakajima
Jan 22, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Reynald HurteauxMarie-Christine Lévy
Jan 25, 2005·Biomaterials·Robert RobitailleJean-Pierre Hallé
Aug 13, 2005·Macromolecular Bioscience·Rohit SrivastavaMichael J McShane
Oct 26, 2005·Colloids and Surfaces. B, Biointerfaces·Mi Hee KimJae Ho Yang
Jan 21, 2006·Journal of Microencapsulation·Lai Wah ChanPaul Wan Sia Heng
Feb 24, 2006·International Journal of Pharmaceutics·Sakchai Wittaya-areekulChureerat Prahsarn
Apr 1, 2006·Biomaterials·Gorka OriveJean-Pierre Hallé
Apr 28, 2006·Expert Opinion on Drug Delivery·Tommasina CovielloFranco Alhaique
Jul 11, 2006·International Journal of Pharmaceutics·George Pasparakis, Nikolaos Bouropoulos
Jul 11, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Meera George, T Emilia Abraham
Sep 6, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Catarina M SilvaFrancisco Veiga
Oct 18, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Kan LiuXing-Zhong Zhao
Nov 9, 2006·Journal of Drug Targeting·Gilberto CoppiValentina Iannuccelli
Mar 27, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tommasina CovielloFranco Alhaique
Apr 7, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rania A H IshakSamia A K Nour
Apr 13, 2007·Biomaterials·Yang YangJunbai Li
May 12, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tasana PitaksuteepongNeti Waranuch
Jun 23, 2007·Biomaterials·Xiaoqin WangDavid L Kaplan
Jun 26, 2007·International Journal of Pharmaceutics·K MladenovskaK Goracinova

❮ Previous
Next ❯

Citations

Aug 3, 2010·Annals of Biomedical Engineering·Hillary E Davis, J Kent Leach
Apr 25, 2012·Journal of Materials Science. Materials in Medicine·Giorgia D'ArrigoPietro Matricardi
Aug 3, 2011·Tissue Engineering. Part B, Reviews·Huanan WangJohn A Jansen
Apr 23, 2013·Advanced Drug Delivery Reviews·Pietro MatricardiFranco Alhaique
Mar 7, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Christian WischkeAndreas Lendlein
Nov 30, 2012·Journal of Biomedicine & Biotechnology·Donghong LiJiancang Liu
Mar 5, 2014·Drug Development and Industrial Pharmacy·Huiming JiangLiangke Zhang
Apr 15, 2009·Drug Development and Industrial Pharmacy·Géraldine HébrardEric Beyssac
Dec 2, 2008·Expert Opinion on Drug Delivery·Zahoor Ahmad, G K Khuller
Jul 28, 2012·Expert Opinion on Drug Delivery·Shirui MaoLuk Chiu Li
May 9, 2013·Expert Opinion on Drug Delivery·Radhika Poojari, Rohit Srivastava
Oct 11, 2015·Journal of Drug Targeting·Abhinav P Acharya, Steven R Little
Mar 31, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Sunil K JainKuldeep Rajpoot
Dec 25, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Sunil K JainAmrish Kumar
Sep 6, 2012·Acta Biomaterialia·Chris OerlemansJ Frank W Nijsen
Aug 26, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·N MenniniP Mura
Feb 26, 2011·Journal of Colloid and Interface Science·Petra HaufováFrantišek Štěpánek
Jul 17, 2009·Journal of Hazardous Materials·Abdellahi ElyMohamed Ould Sid'Ahmed Ould Kankou
Nov 26, 2015·European Polymer Journal·Gaelle C Le GoffPatrick S Doyle
Sep 25, 2015·Soft Matter·Siddhartha DasRabibrata Mukherjee
Jan 18, 2014·Macromolecular Bioscience·Eunkyeong WooKuen Yong Lee
Feb 9, 2012·International Journal of Biological Macromolecules·Seçkin Gülay, Gülşah Şanlı-Mohamed
Jun 12, 2016·Colloids and Surfaces. B, Biointerfaces·Sara PistoneMarianne Hiorth
Jun 20, 2016·Colloids and Surfaces. B, Biointerfaces·Le Truc NguyenKun-Lin Yang
Aug 21, 2016·Colloids and Surfaces. B, Biointerfaces·Hao LiSiddhartha Das
Jan 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Michael T CookDimitris Charalampopoulos
Jul 4, 2013·Biomaterials Science·Johnson H Y ChungGordon G Wallace
Jun 26, 2020·Micromachines·Javid Azimi-BoulaliSergio O Martinez-Chapa
May 9, 2016·ACS Biomaterials Science & Engineering·Vijay Harish SomasundaramManzoor Koyakutty
Jul 4, 2018·The Journal of Physical Chemistry. B·Raja Sampath MaheedharaSiddhartha Das
Jan 16, 2021·ACS Biomaterials Science & Engineering·Anna Puiggalí-JouCarlos Alemán

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Tommasina CovielloFranco Alhaique
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Maja Simonoska CrcarevskaK Goracinova
Progress in Polymer Science
Kuen Yong Lee, David J Mooney
© 2022 Meta ULC. All rights reserved