PMID: 9548338Apr 21, 1998Paper

Recent advances and racial differences in therapeutic strategy to the pineal region tumor

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Shizuo Oi

Abstract

The therapeutic modalities for pineal region tumors in Western countries differ from those in Japan, mainly because of the different patient populations. The majority of pineal region tumors in Japan are radio- and/or chemosensitive, and adjuvant therapy rather than extensive surgery plays the main part in the treatment of these tumors. The specific clinical features of and therapeutic modalities for pineal region tumors, together with racial differences, were analyzed at the joint symposium of the Japanese Society for Pediatric Neurosurgery and the Korean Society for Pediatric Neurosurgery. The results of a cooperative study, together with the collective experience in Korea, confirmed that this specific patient population is nearly identical to the Japanese one. The new therapeutic approaches to pineal region tumors recommended included neuroendoscopic or stereotactic biopsy as a "minimally invasive" initial procedure. The adjuvant therapeutic modalities were further analyzed and neoadjuvant chemotherapy, mainly with cisplatin or carboplatin with or without etoposide (VP-16), was recommended for the treatment of germinoma and nongerminomatous malignant germ cell tumors. "Target radiation therapy" with extensive chemotherapy is...Continue Reading

Citations

Mar 28, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Wuttipong TirakotaiIlhan Celik
Oct 16, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T FietzW U Knauf
May 15, 2010·Future Oncology·Michelle Fèvre-MontangeAnne Jouvet
Aug 2, 2011·Neurosurgery Clinics of North America·Benjamin C Kennedy, Jeffrey N Bruce
Dec 6, 2008·Surgical Neurology·Juha HernesniemiMika Niemelä
Aug 10, 2013·World Neurosurgery·Adam M Sonabend, Jeffrey N Bruce
Nov 23, 2006·Journal of Neuro-oncology·D KeeneUNKNOWN Canadian Pediatric Brain Tumor Consortium

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