Recent Advances in Animal Models of Zika Virus Infection

Virologica Sinica
Shupeng Dong, Qiming Liang

Abstract

An infection by Zika virus (ZIKV), a mosquito-borne flavivirus, broke out in South American regions in 2015, and recently showed a tendency of spreading to North America and even worldwide. ZIKV was first detected in 1947 and only 14 human infection cases were reported until 2007. This virus was previously observed to cause only mild flu-like symptoms. However, recent ZIKV infections might be responsible for the increasing cases of neurological disorders such as Guillain-Barré syndrome and congenital defects, including newborn microcephaly. Therefore, researchers have established several animal models to study ZIKV transmission and pathogenesis, and test therapeutic candidates. This review mainly summarizes the reported animal models of ZIKV infection, including mice and non-human primates.

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Citations

Dec 6, 2019·Journal of Virology·Gage K MorenoDavid H O'Connor
Aug 25, 2020·Birth Defects Research·Sonja A Rasmussen, Denise J Jamieson
Jun 18, 2019·Annual Review of Virology·Dan XuZhiheng Xu
Apr 25, 2020·Cells·Raquel das Neves AlmeidaKelly Grace Magalhaes
Jul 24, 2019·Frontiers in Microbiology·Svetlana F KhaiboullinaSubhash C Verma

Related Concepts

Zika Virus Disease (Disorder)
Zika virus (organism)
Metazoa
Host-Pathogen Interactions
Congenital Abnormality
Guillain-Barre Syndrome
Laboratory mice
Nervous System Disorder
Research Personnel
Virus

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