Recent Advances in Animal Models of Zika Virus Infection

Virologica Sinica
Shupeng Dong, Qiming Liang


An infection by Zika virus (ZIKV), a mosquito-borne flavivirus, broke out in South American regions in 2015, and recently showed a tendency of spreading to North America and even worldwide. ZIKV was first detected in 1947 and only 14 human infection cases were reported until 2007. This virus was previously observed to cause only mild flu-like symptoms. However, recent ZIKV infections might be responsible for the increasing cases of neurological disorders such as Guillain-Barré syndrome and congenital defects, including newborn microcephaly. Therefore, researchers have established several animal models to study ZIKV transmission and pathogenesis, and test therapeutic candidates. This review mainly summarizes the reported animal models of ZIKV infection, including mice and non-human primates.


Nov 17, 2001·Trends in Biotechnology·M S Ko
Mar 22, 2002·Nature Reviews. Immunology·R Medzhitov
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Mar 1, 1954·Transactions of the Royal Society of Tropical Medicine and Hygiene·F N MACNAMARA
Dec 8, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Victoria J DrakeSusan M Smith
Aug 26, 2006·Nature Reviews. Immunology·Kenya Honda, Tadatsugu Taniguchi
Nov 23, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kathleen C F SheehanRobert D Schreiber
Jun 12, 2009·The New England Journal of Medicine·Mark R DuffyEdward B Hayes
Mar 23, 2011·Neuroepidemiology·James J SejvarOliver W Morgan
Feb 14, 2012·Current Opinion in Virology·John W Schoggins, Charles M Rice
Apr 14, 2016·Cell Host & Microbe·Helen M LazearMichael S Diamond
May 6, 2016·PLoS Neglected Tropical Diseases·Stuart D DowallRoger Hewson
Jun 29, 2016·Nature Communications·Dawn M DudleyDavid H O'Connor
Jun 30, 2016·Lancet·Leonelo E Bautista, Ajay K Sethi
Sep 27, 2016·Nature Medicine·Kristina M Adams WaldorfLakshmi Rajagopal
Sep 15, 2016·Stem Cells and Development·Forrest T GoodfellowSteven L Stice
Oct 6, 2016·Nature Medicine·Christa E OsunaJames B Whitney
Nov 1, 2016·Nature·Jennifer GoveroMichael S Diamond
Jan 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ge LiRichard Y Zhao
Apr 13, 2017·Virology Journal·Mukesh KumarVivek R Nerurkar
Apr 22, 2017·Virology·Venkatraman SiddharthanJustin G Julander
May 27, 2017·Emerging Infectious Diseases·Andrew D HaddowFarooq Nasar
Nov 23, 2017·Nature Communications·Yong-Qiang DengCheng-Feng Qin


Dec 6, 2019·Journal of Virology·Gage K MorenoDavid H O'Connor
Aug 25, 2020·Birth Defects Research·Sonja A Rasmussen, Denise J Jamieson
Jun 18, 2019·Annual Review of Virology·Dan XuZhiheng Xu
Apr 25, 2020·Cells·Raquel das Neves AlmeidaKelly Grace Magalhaes
Jul 24, 2019·Frontiers in Microbiology·Svetlana F KhaiboullinaSubhash C Verma

Related Concepts

Zika Virus Disease (Disorder)
Zika virus (organism)
Host-Pathogen Interactions
Congenital Abnormality
Guillain-Barre Syndrome
Laboratory mice
Nervous System Disorder
Research Personnel

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Annales de dermatologie et de vénéréologie
A GuillierC Derancourt
Microbes and Infection
Sébastien BoyerAnna-Bella Failloux
Asian Pacific Journal of Tropical Medicine
Ahmad Ruzain SalehuddinZar Chi Thent
The Lancet Infectious Diseases
Nitwara Wikan, Duncan R Smith
© 2021 Meta ULC. All rights reserved