Recent Advances in Autoimmune Pancreatitis

Gastroenterology
Phil A HartS T Chari

Abstract

Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis that is characterized clinically by frequent presentation with obstructive jaundice, histologically by a dense lymphoplasmacytic infiltrate with fibrosis, and therapeutically by a dramatic response to corticosteroid therapy. Two distinct diseases, type 1 and type 2 AIP, share these features. However, these 2 diseases have unique pancreatic histopathologic patterns and differ significantly in their demographic profiles, clinical presentation, and natural history. Recognizing the popular and long-standing association of the term "AIP" with what is now called "type 1 AIP," we suggest using "AIP" solely for type 1 AIP and to acknowledge its own distinct disease status by using "idiopathic duct-centric chronic pancreatitis" (IDCP) for type 2 AIP. AIP is the pancreatic manifestation of immunoglobulin G4-related disease (IgG4-RD). The etiopathogenesis of AIP and IgG4-RD is largely unknown. However, the remarkable effectiveness of B-cell depletion therapy with rituximab in patients with AIP and IgG4-RD highlights the crucial role of B cells in its pathogenesis. IDCP is less commonly recognized, and little is known about its pathogenesis. IDCP has no biomarker but is associ...Continue Reading

References

Jun 1, 1989·The New England Journal of Medicine·B RockL A Diaz
Aug 1, 1997·Gut·N EctorsG Klöppel
Mar 10, 2001·The New England Journal of Medicine·H HamanoK Kiyosawa
Jun 27, 2003·Pancreas·Randall K PearsonGiorgio Cavallini
Nov 14, 2003·Journal of Gastroenterology·Terumi KamisawaHitoshi Nakajima
Nov 2, 2004·Virchows Archiv : an International Journal of Pathology·Giuseppe ZamboniGünter Klöppel
May 28, 2005·Cellular Immunology·Nancy WoodMarion T Kasaian
Oct 6, 2005·Journal of Cellular and Molecular Medicine·F GuarneriS Benvenga
Dec 13, 2005·Pancreas·Takashi MurakiKendo Kiyosawa
Jul 18, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Suresh T ChariMichael B Farnell
Aug 26, 2006·Journal of Gastroenterology·Kazuichi OkazakiUNKNOWN Research Committee of Intractable Diseases of the Pancreas
Nov 24, 2006·The American Journal of Surgical Pathology·Vikram DeshpandeGregory Y Lauwers
May 24, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoh ZenYasuni Nakanuma
Jun 7, 2007·Mayo Clinic Proceedings·Thomas E WitzigJames A Garity
Sep 18, 2007·Science·Marijn van der Neut KolfschotenPaul W H I Parren
Nov 14, 2007·Gut·Amaar Ghazale, Suresh T Chari
Jan 24, 2008·AJR. American Journal of Roentgenology·Naoki TakahashiSuresh T Chari
Jan 29, 2008·Gastroenterology·Amaar GhazaleMichael B Farnell
Mar 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mark TopazianSuresh T Chari
Jul 5, 2008·Journal of Gastroenterology·Makoto OtsukiUNKNOWN Research Committee of Intractable Pancreatic Diseases provided by the Ministry of Health, Labour and Welfare of Japan and th
Jul 5, 2008·Journal of Gastroenterology·Kazuichi OkazakiToshiro Fukui
Dec 17, 2008·Annals of the Rheumatic Diseases·R EttingerP E Lipsky
Jan 22, 2009·AJR. American Journal of Roentgenology·Kale D BodilySuresh T Chari
Feb 19, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R C AalberseT Rispens
Apr 7, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Neomal S SandanayakeGeorge J M Webster
Apr 29, 2009·Gut·T KamisawaM Omata
May 5, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Suresh T ChariSanthi S Vege
Sep 17, 2009·European Journal of Gastroenterology & Hepatology·Terumi KamisawaNaoko Kubota
Nov 27, 2009·The New England Journal of Medicine·Luca FrulloniAntonio Puccetti
Mar 10, 2010·Journal of Gastroenterology·Terumi KamisawaUNKNOWN Research Committee for Intractable Pancreatic Disease and Japan Pancreas Society
May 19, 2010·Expert Review of Clinical Immunology·Erin Barth, Thomas J Savides
Jun 22, 2010·Pancreas·Suresh T ChariUNKNOWN Autoimmune Pancreatitis International Cooperative Study Group (APICS)

❮ Previous
Next ❯

Citations

Jan 6, 2016·Scandinavian Journal of Gastroenterology·Jose Javier Garcia-MedinaMaria Dolores Pinazo-Duran
Feb 11, 2016·Pancreas·Thomas TschernigReinhard Pabst
Mar 6, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Antonio López-SerranoUNKNOWN Members of the Autoimmune Pancreatitis in Spain Study Group
Jan 29, 2016·Journal of Gastroenterology·Yoh ZenJung Hoon Kim
Sep 10, 2015·Journal of Crohn's & Colitis·Lídia Roque RamosJoana Torres
Jan 2, 2016·The Indian Journal of Surgery·Dilip Parekh, Sathima Natarajan
Nov 23, 2015·Clinical Journal of Gastroenterology·Zinal PatelTuvia Marciano
Mar 31, 2016·Der Radiologe·T Helmberger
May 7, 2015·Case Reports in Medicine·Alessandro MorottiAngelo Guerrasio
Apr 29, 2016·Journal of Digestive Diseases·Sojun HoshimotoHitoshi Sugiura
Mar 8, 2016·Lancet·Shounak Majumder, Suresh T Chari
Jun 5, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Lídia Roque RamosJoana Torres
Jun 29, 2016·Medical Molecular Morphology·Hiep Nguyen Canh, Kenichi Harada
Jul 8, 2016·Journal of Crohn's & Colitis·Nerea Hernanz, Antonio Lopez-Sanroman
Jun 25, 2016·Current Opinion in Gastroenterology·Walter G Park
Jun 28, 2016·Postgraduate Medical Journal·Francisco José Fernández-FernándezMaría José Bello-Peón
Mar 16, 2017·Nature Reviews. Gastroenterology & Hepatology·Sohail Z Husain, Arvind I Srinath
Apr 5, 2017·The American Journal of Gastroenterology·Isabelle ScheersTanja Gonska
Apr 5, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomohiro WatanabeMasatoshi Kudo
Aug 27, 2017·Current Treatment Options in Gastroenterology·Phil A HartKazuichi Okazaki
Jun 21, 2018·Expert Review of Gastroenterology & Hepatology·Nicolò de PretisLuca Frulloni
Jun 28, 2018·F1000Research·Angela Pham, Christopher Forsmark
Nov 4, 2016·ACG Case Reports Journal·Susana MarquesPedro Pinto-Marques
Sep 14, 2016·ACG Case Reports Journal·Rishi BoliaMark R Oliver
Jan 12, 2019·Postgraduate Medicine·Tien-Ching Lin, Wei-Lun Chang
Nov 15, 2018·Journal of Pathology and Translational Medicine·Mee-Jeong KimSeung-Mo Hong
Feb 11, 2020·Insights Into Imaging·Ali Devrim KaraosmanogluPeter F Hahn
Dec 1, 2017·Clinical Nuclear Medicine·Lichun ZhengLi Huo
Nov 26, 2019·The American Journal of Gastroenterology·Phil A Hart, Darwin L Conwell
Sep 29, 2019·Abdominal Radiology·Kunal KothariFrank H Miller
Sep 8, 2019·Abdominal Radiology·Camila Lopes VendramiFrank H Miller
Apr 30, 2020·Rheumatology·Federica MaritatiAugusto Vaglio
May 2, 2019·Clinical Journal of Gastroenterology·Giovanna Del Vecchio BlancoOmero Alessandro Paoluzi
Apr 19, 2020·Journal of Pediatric Gastroenterology and Nutrition·Isabelle ScheersTanja Gonska

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Deutsche medizinische Wochenschrift
G BeyerJ Mayerle
Pancreas
S T ChariAutoimmune Pancreatitis International Cooperative Study Group (APICS)
Journal of Gastroenterology
Shigeyuki KawaStudy Group for Pancreatitis Complicated with Inflammatory Bowel Disease organized by The Research Committee for Intractable
© 2021 Meta ULC. All rights reserved