PMID: 15374279Sep 1, 1994Paper

Recent advances in basic aging research on the nervous system in Japan

Archives of Gerontology and Geriatrics
K Kanda

Abstract

Recent studies on aging of the nervous system are reviewed with special reference to neuronal cell death, compensatory reaction, trophic factors, brain cholinergic systems and the autonomic nervous system. Studies on spinal motoneurons labeled with a tracer substance transported retrogradely demonstrated differential age effect on different types. Compensatory reactions were also seen among surviving motoneurons. Motoneuronal survival appears to be correlated with the amount of activity. However, the causal relationship between them is not yet conclusive. The effects of nerve growth factor on sympathetic and dorsal-root ganglion cells seem to be well preserved in the aged, although there are some controversial findings on the ratio of NGF-dependent neurons versus NGF-independent neurons. It has been shown that acidic fibroblast growth factor or other substances may prevent degeneration of the basal forebrain cholinergic neurons and improve memory and learning performance in aged animals. The cholinergic system also regulates the regional cerebral blood flow, and this function seems to be well maintained in aged rats. Microneurography techniques have revealed increased activity of postganglionic sympathetic nerves innervating mu...Continue Reading

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Citations

Jul 21, 2009·Forensic Science, Medicine, and Pathology·Neil E I Langlois
May 12, 2020·Journal of Alzheimer's Disease : JAD·Claude RobertCharles-Daniel Arreto

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