Recent advances in bio-orthogonal and dynamic crosslinking of biomimetic hydrogels.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Matthew R ArkenbergChien-Chi Lin

Abstract

In recent years, dynamic, 'click' hydrogels have been applied in numerous biomedical applications. Owing to the mild, cytocompatible, and highly specific reaction kinetics, a multitude of orthogonal handles have been developed for fabricating dynamic hydrogels to facilitate '4D' cell culture. The high degree of tunability in crosslinking reactions of orthogonal 'click' chemistry has enabled a bottom-up approach to install specific biomimicry in an artificial extracellular matrix. In addition to click chemistry, highly specific enzymatic reactions are also increasingly used for network crosslinking and for spatiotemporal control of hydrogel properties. On the other hand, covalent adaptable chemistry has been used to recapitulate the viscoelastic component of biological tissues and for formulating self-healing and shear-thinning hydrogels. The common feature of these three classes of chemistry (i.e., orthogonal click chemistry, enzymatic reactions, and covalent adaptable chemistry) is that they can be carried out under ambient and aqueous conditions, a prerequisite for maintaining cell viability for in situ cell encapsulation and post-gelation modification of network properties. Due to their orthogonality, different chemistries c...Continue Reading

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Citations

Feb 4, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mijung JungChang Seok Ki
Mar 2, 2021·Advanced Science·Barbara Blanco-FernandezJoão F Mano
Apr 10, 2021·Chemical Reviews·Benjamin D FairbanksChristopher N Bowman
Jun 5, 2021·ACS Biomaterials Science & Engineering·Nicola Contessi NegriniAdam D Celiz
Jun 11, 2021·Biofabrication·Norman M DrzeniekShay Soker
Sep 3, 2021·Chemical Reviews·Franck J VernereyStephanie J Bryant

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