Recent advances in bioreactors for cell-based therapies

F1000Research
Makeda Stephenson, Warren Grayson

Abstract

Bioreactors have become indispensable tools in the cell-based therapy industry. Various forms of bioreactors are used to maintain well-controlled microenvironments to regulate cell growth, differentiation, and tissue development. They are essential for providing standardized, reproducible cell-based products for regenerative medicine applications or to establish physiologically relevant in vitro models for testing of pharmacologic agents. In this review, we discuss three main classes of bioreactors: cell expansion bioreactors, tissue engineering bioreactors, and lab-on-a-chip systems. We briefly examine the factors driving concerted research endeavors in each of these areas and describe the major advancements that have been reported in the last three years. Emerging issues that impact the commercialization and clinical use of bioreactors include (i) the need to scale up to greater cell quantities and larger graft sizes, (ii) simplification of in vivo systems to function without exogenous stem cells or growth factors or both, and (iii) increased control in the manufacture and monitoring of miniaturized systems to better capture complex tissue and organ physiology.

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Citations

May 2, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Pere DostaNatalie Artzi
Aug 23, 2020·International Journal of Molecular Sciences·Kar Wey YongAlistair C Cowie
Oct 9, 2019·International Journal of Molecular Sciences·Ayidah AlghuwainemBatla Alsowayan
Jul 17, 2020·Frontiers in Bioengineering and Biotechnology·Ang-Chen TsaiYan Li
Aug 9, 2020·Frontiers in Bioengineering and Biotechnology·Meletios-Nikolaos DoulgkeroglouDimitrios I Zeugolis
Aug 4, 2020·Journal of Tissue Engineering·Elena García-GaretaKarin Vicente Greco
Jan 27, 2020·Trends in Biotechnology·Enrico FritscheMohamed Abou-El-Enein
Apr 15, 2021·Journal of Biological Engineering·Oscar Fabian Garcia-AponteBence Kozma
Nov 3, 2021·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Araceli Rivera-OrdazLorenza Lazzari

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Methods Mentioned

BETA
chip

Software Mentioned

DynaMag
CliniMACS Prodigy
WAVE
CliniMACS Prodigy system

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