Recent advances in CDK inhibitors for cancer therapy

Future Medicinal Chemistry
Amy B HeptinstallIan R Hardcastle

Abstract

Inhibition of CDKs is an attractive approach to cancer therapy due to their vital role in cell growth and transcription. Pan-CDK inhibitors have shown some clinical benefit, and trials are ongoing. Selective CDK4 and CDK6 inhibitors have been licensed for the treatment of hormone responsive, RB-positive breast cancer in combination with antihormonal agents. Selective inhibitors of CDKs 5, 7, 8, 9 and 12 have been identified across a range of chemotypes.

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Citations

Jun 30, 2019·The Journal of Pharmacology and Experimental Therapeutics·Seung-Youn JungJie-Young Song
Mar 27, 2020·Future Medicinal Chemistry·Minmin WangSheng Jiang
Jan 5, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Xin WangRong Xiang
Dec 12, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Stephen J Marx, David Goltzman
Dec 18, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Clara AlconJoan Montero
Jun 21, 2021·European Journal of Medicinal Chemistry·Haochao ZhangZhiyan Xiao
Jul 20, 2021·Frontiers in Chemistry·Fei YuJihong Zhang
Sep 8, 2021·Journal of Hematology & Oncology·Haobin LiJiang-Jiang Qin
Dec 24, 2021·Future Medicinal Chemistry·Bin YuJinlei Bian

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Methods Mentioned

BETA
xenografts
xenograft
surface
x-ray co-crystallography
co-crystallization
two-hybrid
protein binding assay

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