Recent advances in cerebral cavernous malformation research

Vessel Plus
Akhil Padarti, Jun Zhang

Abstract

Cerebral cavernous malformations (CCM) are manifested by microvascular lesions characterized by leaky endothelial cells with minimal intervening parenchyma predominantly in the central nervous system predisposed to hemorrhagic stroke, resulting in focal neurological defects. Till date, three proteins are implicated in this condition: CCM1 (KRIT1), CCM2 (MGC4607), and CCM3 (PDCD10). These multi-domain proteins form a protein complex via CCM2 that function as a docking site for the CCM signaling complex, which modulates many signaling pathways. Defects in the formation of this signaling complex have been shown to affect a wide range of cellular processes including cell-cell contact stability, vascular angiogenesis, oxidative damage protection and multiple biogenic events. In this review we provide an update on recent advances in structure and function of these CCM proteins, especially focusing on the signaling cascades involved in CCM pathogenesis and the resultant CCM cellular phenotypes in the past decade.

Citations

Aug 6, 2020·Biomedicines·Vasily N SukhorukovAlexander N Orekhov
Aug 6, 2020·International Journal of Molecular Sciences·Yuliya V MarkinaAlexander N Orekhov
Sep 15, 2020·Chinese Neurosurgical Journal·Johnathan Abou-FadelJun Zhang
Nov 5, 2019·Scientific Reports·Xiaoting JiangJun Zhang
Jun 13, 2020·Frontiers in Pharmacology·Alexander M MarkinAlexander N Orekhov
Nov 26, 2020·Open Biology·Valerie L Su, David A Calderwood
Dec 25, 2019·Heliyon·Johnathan Abou-FadelJun Zhang
Jan 10, 2020·Cellular Signalling·Federica FinettiLorenza Trabalzini

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Methods Mentioned

BETA
dynamic
electrophoresis
X-ray
two-hybrid
GTPase
Co-IP
pull-down
pharmacotherapy

Software Mentioned

Co
IP

Related Concepts

Related Feeds

Cavernous Hemangioma

Cavernous hemangioma is a blood vessel defect or benign tumor that leads to leakage of blood to the surrounding tissues. This can occur in several organs including the brain, which can lead to seizures. Discover the latest research on cavernous hemangiomas here.

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