Recent Advances in Copper Intercalators as Anticancer Agents

Journal of Fluorescence
C Shobha DeviPenumaka Nagababu

Abstract

Copper is a part of various enzymes and helps them to function properly. It can be effectively used to produce promising anticancer drugs and presently, many studies are being pursued worldwide on the development of copper-based complexes as potential anticancer drugs. Herein, we briefly discuss the importance of reactive oxygen species in biological applications and copper(II) complexes as anticancer drugs. The anti-angiogenic properties of mono-nuclear copper(II) complexes have been demonstrated by in vivo chick embryo angiogenesis analysis. The plausible mechanism behind anticancer activity of these complexes is by the formation of excessive intracellular Reactive Oxygen Species (ROS). ROS is a composite term used for oxygen derivative non-radicals and free radicals of highly reactive components, that enhances the killing response of immune cells to microbial invasion. Previous reports have shown that ROS plays an important role as a messenger in cell cycling and normal cell signal transduction. Graphical Abstract The generation of singlet oxygen and healing the tumor cells with singlet oxygen in presence of UV-light.

References

Feb 1, 1993·Photochemistry and Photobiology·N L OleinickM E Kenney
Oct 26, 1999·Drug Discovery Today·W M Sharman van Lier JE
Jan 8, 2000·Journal of Inorganic Biochemistry·J D RobertsN Farrell
Nov 23, 2000·Nature·T Finkel, N J Holbrook
Dec 26, 2001·Chemical Reviews·M J ClarkeD R Frasca
Jan 5, 2002·Physiological Reviews·Wulf Dröge
May 1, 2002·Redox Report : Communications in Free Radical Research·Stefan I Liochev, Irwin Fridovich
May 2, 2003·Nature Reviews. Cancer·Peter Friedl, Katarina Wolf
Feb 1, 1961·Journal of Molecular Biology·L S LERMAN
Mar 18, 2004·Antioxidants & Redox Signaling·Valerian E Kagan, Peter J Quinn
Mar 20, 2004·Nature Reviews. Drug Discovery·Kevin J BarnhamAshley I Bush
Sep 21, 2004·Annual Review of Plant Biology·Klaus Apel, Heribert Hirt
Sep 24, 2004·Dalton Transactions : an International Journal of Inorganic Chemistry·Tarkeshwar GuptaAkhil R Chakravarty
Jan 11, 2005·Current Medicinal Chemistry·R Martínez, L Chacón-García
May 17, 2005·Current Medicinal Chemistry·M ValkoM T D Cronin
Feb 21, 2006·Chemical Research in Toxicology·James D West, Lawrence J Marnett
May 10, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Xiaoqiang CaiGuolin Zou
Dec 15, 2006·Journal of the American Chemical Society·Seiji KomedaLoren Dean Williams
Aug 19, 2007·Nature·Toren FinkelMaria A Blasco
May 29, 2008·Clinical and Experimental Pharmacology & Physiology·Lydia FinneyDavid Glesne
Apr 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Dongdong LiShiping Yan
Sep 15, 2010·Indian Journal of Pharmaceutical Sciences·M A NeelakantanT Jeyakumar
Feb 23, 2011·International Journal of Molecular Sciences·Ralee Spooner, Ozlem Yilmaz
Mar 31, 2011·Accounts of Chemical Research·Hong-Ke Liu, Peter J Sadler
Jul 20, 2011·Nature Chemical Biology·Bryan C Dickinson, Christopher J Chang
Oct 27, 2011·Free Radical Biology & Medicine·Balaraman KalyanaramanHarry Ischiropoulos
Oct 13, 2012·Chemistry : a European Journal·Kogularamanan SuntharalingamRamon Vilar
Nov 16, 2012·Nanoscale·Ayan Kumar BaruiChitta Ranjan Patra
Dec 12, 2012·Physical Review Letters·M AblikimUNKNOWN BESIII Collaboration
Sep 3, 2013·Antioxidants & Redox Signaling·Claudia N Paiva, Marcelo T Bozza
Oct 10, 2013·Chemical Reviews·Carlo SantiniCristina Marzano
Feb 8, 2014·Theranostics·Sudip MukherjeeChitta Ranjan Patra
May 9, 2014·Inorganic Chemistry·Zara MolphyAndrew Kellett
Jun 13, 2015·Journal of Medicinal Chemistry·Penumaka NagababuBojja Sreedhar

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Citations

Oct 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vaiyapuri Subbarayan PeriasamyMohammad Abdulkader Akbarsha
Oct 9, 2020·Cancers·Caroline MolinaroKatia Cailliau
Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nidia D Corona-MotoliniaEnrique González-Vergara
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mihaela BadeaRodica Olar
Jun 13, 2020·Journal of Inorganic Biochemistry·Beatriz Martínez-ValenciaEnrique González-Vergara
Nov 30, 2018·Chemical Reviews·Bernhard EnglingerWalter Berger
Aug 30, 2021·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Gabriel Berbigier RodriguesJoão Antonio Pêgas Henriques

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Datasets Mentioned

BETA
GM05757

Methods Mentioned

BETA
fluorescence microscopy

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