Recent advances in de-intensification of radiotherapy in elderly cancer patients

F1000Research
Isacco DesideriLorenzo Livi

Abstract

Cancer in the elderly remains an evolving issue and a health challenge. Several improvements in the radiotherapy field allow the delivery of higher doses/fractions with a safe toxicity profile, permitting the reduction of radiation treatment protocols in the elderly. Regarding breast, prostate, and lung cancer, the under-representation of older patients in clinical trials limits the extension of treatment recommendations to elderly patients in routine clinical practice. Among the feasible alternatives to standard whole breast radiotherapy (WBRT) in older patients are shorter courses using higher hypofractionation (HF) and accelerated partial breast irradiation (APBI). The boost continues to be used in women at high risk of local recurrence but is less widely accepted for women at lower risk and patients over 70 years of age. Regarding prostate cancer, there are no published studies with a focus on the elderly. Current management decisions are based on life expectancy and geriatric assessment. Regimens of HF and ultra-HF protocols are feasible strategies for older patients. Several prospective non-randomized studies have documented the safe delivery of ultra-HF for patients with localized prostate cancer, and multiple phase III ...Continue Reading

References

Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P RomestaingJ P Gérard
Nov 12, 2002·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Csaba PolgárGyörgy Németh
Mar 28, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Martin WeinmannCarsten Bokemeyer
Oct 3, 2006·Seminars in Radiation Oncology·Randall K Ten Haken, Theodore S Lawrence
Jun 2, 2007·Cancer·Steven E SchildUNKNOWN North Central Cancer Treatment GroupThis study was conducted as a collaborative trial of the North Central Cancer Treatment
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry BartelinkLaurence Collette
Sep 2, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sandra ColletteUNKNOWN EORTC Radiation Oncology Group
Jun 12, 2009·The New England Journal of Medicine·Michel BollaUNKNOWN EORTC Radiation Oncology Group and Genito-Urinary Tract Cancer Group
Jan 19, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Neil BaymanCorinne Faivre-Finn
Apr 21, 2010·The Cancer Journal·Anand Swaminath, Laura A Dawson
Apr 28, 2011·Cancer·Timothy J DaskivichMark S Litwin
Jun 1, 2011·Frontiers of Radiation Therapy and Oncology·Vincent W C WuC Clifton Ling
Jul 15, 2011·The New England Journal of Medicine·Christopher U JonesWilliam U Shipley
Jul 22, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·David PalmaSuresh Senan
Jan 8, 2013·Journal of the National Cancer Institute·Silvia C Formenti, Sandra Demaria
Mar 26, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R W BlameyS E Pinder
May 22, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin S HughesWilliam C Wood
Mar 15, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I H KunklerUNKNOWN SIOG Radiotherapy Task Force
Jun 18, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L DecosterM Extermann
Dec 17, 2014·The Lancet Oncology·Harry BartelinkUNKNOWN European Organisation for Research and Treatment of Cancer Radiation Oncology and Breast Cancer Groups
Jan 7, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Justin E BekelmanKatrina Armstrong
Jan 22, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lorenzo LiviSimonetta Bianchi
Feb 18, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ronald C ChenSuneil Jain
Apr 6, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W Robert LeeHoward M Sandler
Aug 12, 2016·International Journal of Radiation Oncology, Biology, Physics·Shayna L ShowalterTimothy N Showalter
Nov 12, 2016·Aging Clinical and Experimental Research·Francesca Maria GiuglianoPaolo Muto
Mar 16, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles N CattonMark N Levine

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Citations

Aug 28, 2021·Deutsche medizinische Wochenschrift·Valentin Goede, Michael von Bergwelt-Baildon

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Methods Mentioned

BETA
surgical resection

Clinical Trials Mentioned

ISRCTN45905321
NCT01794403
NCT01584258
NCT00840749
NCT00687986

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