Recent Advances in Diagnosing Chronic Pulmonary Aspergillosis

Frontiers in Microbiology
Takahiro Takazono, Koichi Izumikawa

Abstract

Purpose: The diagnosis of chronic pulmonary aspergillosis (CPA) is occasionally complicated due to poor sensitivity of mycological culture and colonization of Aspergillus species in the airway. Several diagnostic methods have been developed for the diagnosis of invasive pulmonary aspergillosis; however, their interpretation and significance are different in CPA. This study aimed to review the recent advances in diagnostic methods and their characteristics in the diagnosis of CPA. Recent findings: Radiological findings of lung, histopathology, and culture are the gold standard of CPA diagnosis. Serodiagnosis methods involving the use of galactomannan and β-D-glucan have low sensitivity and specificity. An Aspergillus-specific IgG antibody assay showed good performance and had better sensitivity and reproducibility than conventional precipitant antibody assays. Currently, it is the most reliable method for diagnosing CPA caused by Aspergillus fumigatus, but evidence on its effectiveness in diagnosing CPA caused by non-fumigatus Aspergillus is lacking. Newly developed lateral flow device Aspergillus and detection of volatile organic compounds in breath have potential, but evidence on its effectiveness in diagnosing CPA is lacking....Continue Reading

References

Aug 5, 2003·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M L UffrediG Kac
Sep 17, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David W DenningHelen Sambatakou
Aug 23, 2005·Medical Mycology·W W HopeD W Denning
Oct 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yoshihiro KobashiMikio Oka
Apr 20, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Johan A MaertensPaul E Verweij
Mar 21, 2009·Medical Mycology·Stephen T ChambersMichael J Epton
Aug 8, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yasuhiko KitasatoHisamichi Aizawa
Nov 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Johan MaertensKatrien Lagrou
Nov 17, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hae-Seong NamWon-Jung Koh
Aug 20, 2010·Medical Mycology·John W Baddley
Aug 28, 2010·The Journal of Infection·Shigeru KohnoUNKNOWN Japan Chronic Pulmonary Aspergillosis Study Group (JCPASG)
Mar 4, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Drosos E KarageorgopoulosMatthew E Falagas
Apr 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David W DenningDavid S Perlin
Oct 18, 2011·Emerging Infectious Diseases·Jan W M van der LindenPaul E Verweij
Nov 22, 2011·PLoS Pathogens·Thierry FontaineJean-Paul Latgé
May 10, 2012·Medical Mycology·Koichi IzumikawaShigeru Kohno
Jul 12, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J CadranelP Germaud
Jan 22, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C G BaxterM D Richardson
Jan 28, 2014·The Journal of Infection·Beomsu ShinKyeongman Jeon
Jan 31, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Koichi IzumikawaShigeru Kohno
Sep 10, 2014·American Journal of Respiratory and Critical Care Medicine·Juergen PrattesMartin Hoenigl
Oct 25, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sophia KooFrancisco M Marty
May 17, 2015·Medical Mycology·Iain D PageDavid W Denning
May 20, 2015·Emerging Infectious Diseases·J W M van der LindenP E Verweij
Jun 27, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P Lewis WhiteJ Peter Donnelly
Dec 25, 2015·The European Respiratory Journal·David W DenningUNKNOWN European Society for Clinical Microbiology and Infectious Diseases and European Respiratory Society
Feb 24, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S ImbertA Fekkar
Mar 25, 2016·Journal of Clinical Microbiology·Satoru FujiuchiYoshinobu Ohsaki
Aug 3, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas F PattersonJohn E Bennett
Aug 20, 2016·BMC Pulmonary Medicine·Eavan G MuldoonDavid W Denning
Jan 13, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jacques F MeisPaul E Verweij
Feb 10, 2017·The European Respiratory Journal·David LowesDavid W Denning
Sep 16, 2017·The Journal of Infectious Diseases·Anuradha ChowdharyJacques F Meis

❮ Previous
Next ❯

Citations

Apr 9, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Masato TashiroKoichi Izumikawa
Dec 8, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Richard KwizeraFelix Bongomin
Mar 18, 2020·PloS One·Cláudia Elizabeth Volpe ChavesAnamaria Mello Miranda Paniago
Nov 15, 2019·Clinical Microbiology Reviews·Jean-Paul Latgé, Georgios Chamilos
Aug 31, 2020·The Journal of Antimicrobial Chemotherapy·Lilyann Novak-FrazerRiina Rautemaa-Richardson
Oct 13, 2020·Current Clinical Microbiology Reports·Krystal Y Chung, Jessica C S Brown

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
lavage
PCR
ELISA
bronchoalveolar lavage

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.