Recent advances in diagnostic technologies for autoimmune diseases

Autoimmunity Reviews
Mario PlebaniMonica Maria Mion

Abstract

The investigation of autoimmunity provides an interest challenge in "omics" research and, particularly, proteome research, as autoimmune diseases are common disorders of unsolved etiology that occur in a wide range of manifestations, in all of which tissues and organs are attacked by the body's own immune system. Autoantibodies are a hallmark of many autoimmune diseases and the presence of autoantibodies is a distinctive and key characteristic of autoimmune diseases. Conventionally, the study of autoimmune response has always been conducted by analysing the presence and/or concentration of individual antibodies in biological fluids. New proteomic techniques allow the simultaneous identification/measurement of different autoantibodies in sera of patients suffering from autoimmune diseases. The possibility of simultaneously measuring a number of correlated analytes appears to be very interesting for analytical reasons (reduced volumes of biological samples, reagents and low costs), logistical/managerial reasons, and pathophysiological reasons (combination of markers in disease-oriented or organ-oriented profiling). In particular, we describe data collected by using high-throughput techniques such as antigen microarrays and mass s...Continue Reading

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Citations

Apr 9, 2011·Molecular & Cellular Proteomics : MCP·Yasuhiro KatsumataMasako Hara
Mar 19, 2013·PloS One·Mina Kalantari-DehaghiSergei A Grando
Feb 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Thomas SajdaAnimesh A Sinha
Dec 18, 2014·International Journal of Molecular Sciences·Paolo ColombaGiovanni Duro
Mar 13, 2016·Medical Hypotheses·Aline Lauria P AbrãoLicia Maria Henrique da Mota
Dec 12, 2012·Autoimmunity Reviews·Elisa MenegattiDario Roccatello
Dec 29, 2009·Journal of Autoimmunity·Pietro Invernizzi
Apr 28, 2009·Autoimmunity Reviews·Klaartje SomersVeerle Somers
Sep 18, 2009·Annals of the New York Academy of Sciences·Chiara BonaguriCesare Monica
Jul 22, 2014·Journal of Molecular Recognition : JMR·Mahmoud Al-MajdoubMichael O Glocker
Jul 3, 2016·Clinical Reviews in Allergy & Immunology·Mandy SowaDirk Roggenbuck
Aug 27, 2015·World Journal of Experimental Medicine·Peter Lea
May 23, 2014·Immune Network·Ho-Youn KimSang-Heon Lee

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Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.