Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease

World Journal of Hepatology
Tannaz EslamparastAzita Hekmatdoost

Abstract

Nonalcoholic fatty liver disease (NAFLD) is currently known as the most common liver problem, characterized by excessive lipid accumulation in hepatocytes, which may progress to other liver diseases such as nonalcoholic steatohepatitis, hepatic tissue fibrosis, liver cirrhosis, and failure or hepatocellular carcinoma. Since NAFLD is positively associated with the development of obesity, insulin resistance, and ultimately type 2 diabetes mellitus, it is often regarded as the hepatic manifestation of the metabolic syndrome. No pharmacologic treatment has yet been proven for this disease. For most patients with presumed or confirmed NAFLD, the only proven strategy is to offer lifestyle advice that can lead to sustained weight loss. Since insulin resistance, oxidative stress, inflammation, and necro-apoptosis are involved in NAFLD pathogenesis, it seems that every potential therapeutic agent should target one or some of these pathologic events. There are many well known anti-oxidants, anti-inflammatory, and insulin sensitizer dietary supplements which have shown beneficial effects on NAFLD improvement in animal and human studies. The purpose of this review is to explore the existing evidences on dietary supplements considered to ha...Continue Reading

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Citations

Feb 21, 2016·The Journal of Nutritional Biochemistry·Paola DongiovanniLuca Valenti
Mar 18, 2016·International Journal of Food Sciences and Nutrition·Zahra YariAzita Hekmatdoost
Jul 30, 2016·Nature Reviews. Endocrinology·Xianlin Han
Jul 21, 2016·International Journal of Food Sciences and Nutrition·Azita HekmatdoostHossein Poustchi
Jan 27, 2019·Food Science & Nutrition·Mehrnaz Nikkhah BodaghAzita Hekmatdoost
Apr 11, 2019·Journal of Digestive Diseases·Asieh MansourParvin Mirmiran
Jul 28, 2016·World Journal of Hepatology·Vishnubhotla Venkata Ravi KanthDuvvuru Nageshwar Reddy
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Apr 27, 2017·World Journal of Hepatology·Zeinab MokhtariAzita Hekmatdoost
Oct 21, 2016·Journal of the Science of Food and Agriculture·Maryam NooriAzita Hekmatdoost
Jul 4, 2015·World Journal of Hepatology·Ludovico Abenavoli
Nov 12, 2015·World Journal of Hepatology·Mehran RahimlouAzita Hekmatdoost
Jan 27, 2018·Indian Journal of Clinical Biochemistry : IJCB·Hadi EmamatAzita Hekmatdoost

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