Recent advances in heart transplantation

F1000Research
Michelle M Kittleson

Abstract

Despite advances in medical and electrical therapies for heart failure, morbidity and mortality remain high and patients often progress to end-stage heart failure. Over the last five decades, heart transplantation is considered a standard therapy for select patients with end-stage heart failure. However, while heart transplantation has become a treatment of choice for end-stage heart failure, challenges still exist for improvement in the short- and long-term outcomes. While there is an increase in the number of patients with end-stage heart failure, the number of donor organs remains a major limiting factor. Heart transplantation candidates in the current era are also more complex: older, antigen-sensitized, and on mechanical circulatory support at the time of listing and transplant. Such potential heart transplant recipients have an increased chance of problems, including antibody-mediated rejection and primary graft dysfunction. Recent advances could address the current challenges and include: 1) attempts to expand the pool of donor hearts; 2) changes in heart transplantation allocation policy allowing for more equitable organ distribution; and 3) advances in the management of antibody sensitization. Developments in these are...Continue Reading

References

Jan 26, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M C DengUNKNOWN CARGO Investigators
Jul 19, 2008·The New England Journal of Medicine·Ashley A VoStanley C Jordan
Mar 17, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jon KobashigawaUNKNOWN Consensus Conference Participants
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Josef StehlikDavid D Eckels
Apr 24, 2010·The New England Journal of Medicine·Michael X PhamUNKNOWN IMAGE Study Group
May 21, 2010·Clinical Transplantation·Peter M EckmanGonzalo V Gonzalez-Stawinski
Dec 1, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J M CeckaM S Leffell
Feb 9, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jon KobashigawaUNKNOWN Consensus Conference Participants
Sep 29, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M D StegallJ M Gloor
Oct 5, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jignesh PatelJon Kobashigawa
May 26, 2012·The Annals of Thoracic Surgery·Arman KilicJohn V Conte
Aug 15, 2012·Current Opinion in Organ Transplantation·Michelle M Kittleson, Jon A Kobashigawa
Nov 13, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Adriana ZeeviSteven Webber
Sep 27, 2013·The New England Journal of Medicine·Alexandre LoupyXavier Jouven
May 24, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Simon MesserSteven Tsui
Jun 20, 2014·Science Translational Medicine·Iwijn De VlaminckKiran K Khush
Dec 24, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D M MeyerJ C Cleveland
Dec 24, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A KobashigawaUNKNOWN Forum Participants
Jan 30, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Colvin-AdamsB L Kasiske
Feb 14, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K K KhushB A Goldstein
Oct 25, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lars H LundUNKNOWN International Society for Heart and Lung Transplantation
Jan 5, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M ColvinB L Kasiske
May 17, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J KobashigawaJ Stehlik

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