Recent advances in intensity modulated radiotherapy and proton therapy for esophageal cancer

Expert Review of Anticancer Therapy
Mian Xi, Steven H Lin

Abstract

Radiotherapy is an important component of the standard of care for esophageal cancer. In the past decades, significant improvements in the planning and delivery of radiation techniques have led to better dose conformity to the target volume and improved normal tissue sparing. Areas covered: This review focuses on the advances in radiotherapy techniques and summarizes the availably dosimetric and clinical outcomes of intensity-modulated radiation therapy (IMRT), volumetric modulated arc therapy, proton therapy, and four-dimensional radiotherapy for esophageal cancer, and discusses the challenges and future development of proton therapy. Expert commentary: Although three-dimensional conformal radiotherapy is the standard radiotherapy technique in esophageal cancer, the retrospectively comparative studies strongly suggest that the dosimetric advantage of IMRT over three-dimensional conformal radiotherapy can translate into improved clinical outcomes, despite the lack of prospective randomized evidence. As a novel form of conventional IMRT technique, volumetric modulated arc therapy can produce equivalent or superior dosimetric quality with significantly higher treatment efficiency in esophageal cancer. Compared with photon therapy...Continue Reading

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Citations

Jan 12, 2020·Journal of Applied Clinical Medical Physics·Wanfu YangJun Shang
Oct 16, 2019·Oncology Letters·Fei YaoQingming Wu
Jan 25, 2021·Journal of Experimental & Clinical Cancer Research : CR·Fangyu ChenXinchen Sun
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Wenfang ChengJiancheng Li
Jun 16, 2021·Esophagus : Official Journal of the Japan Esophageal Society·Kaiqi LanMian Xi

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