Recent advances in intravenous delivery of poorly water-soluble compounds

Expert Opinion on Drug Delivery
Yi ShiLuk Chiu Li

Abstract

In recent years, with the widespread application of high-throughput screening technologies in drug discovery, an increasing number of new chemical entities with extremely poor aqueous solubility have been generated. Their poor solubility represents a major challenge for formulation of these compounds for both oral and parenteral administration. Formulations for intravenous (i.v.) application are of significant importance because they are frequently used in several key therapeutic areas, such as oncology and anesthesia. Furthermore, i.v. formulations of new compounds are often needed to determine basic biopharmaceutical parameters and to obtain proof of concept results in the early phase of product development. This review provides an overview of the recent advances in formulation approaches and drug delivery technologies for poorly water-soluble compounds applicable to i.v. administration. The advantages and disadvantages of different strategies are highlighted and an expert opinion on each technical field is presented.

References

Jul 3, 1975·Biochimica Et Biophysica Acta·D PapahadjopoulosG Poste
Jan 1, 1987·Annals of the New York Academy of Sciences·S S DavisR Kirsh
Jan 1, 1996·Journal of Drug Targeting·P G TardiP R Cullis
Dec 22, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·C AllenA Eisenberg
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H MaedaK Hori
Jul 6, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·J C DeToledo, R E Ramsay
Feb 24, 2001·Annals of the New York Academy of Sciences·J W SingerS Wallace
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·J W SingerP de Vries
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·T NakanishiK Kataoka
Aug 8, 2001·International Journal of Pharmaceutics·T Loftsson, M Masson
Aug 31, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H GelderblomA Sparreboom
Feb 19, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Dirk L Teagarden, David S Baker
Mar 19, 2002·Advanced Drug Delivery Reviews·Afsaneh LavasanifarGlen S Kwon
May 15, 2002·Chembiochem : a European Journal of Chemical Biology·Ulrik BoasE W Meijer
Jun 6, 2002·Critical Reviews in Therapeutic Drug Carrier Systems·Alexander V Kabanov, Valery Yu Alakhov
Jun 27, 2002·Journal of the American Chemical Society·Xinli LiuThomas G Burke
Jul 12, 2002·Cancer Chemotherapy and Pharmacology·Daniel J BooserGabriel N Hortobagyi
Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexander V KabanovValery Yu Alakhov
Aug 22, 2002·Current Cancer Drug Targets·Ron H J MathijssenAlex Sparreboom
Nov 12, 2002·Pharmaceutical Research·Anatoly N LukyanovVladimir P Torchilin
Dec 20, 2002·Clinical Pharmacokinetics·James H FischerPatricia A Fischer
Dec 28, 2002·Journal of Medicinal Chemistry·Rama BhattPeter Klein
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric K RowinskyAnthony W Tolcher
Feb 21, 2003·International Journal of Pharmaceutics·Margarita ValeroLicesio J Rodríguez
Feb 21, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Elaine Merisko-LiversidgeEugene R Cooper
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas WunderChristoph Fiehn
Jun 6, 2003·International Journal of Pharmaceutics·Parag KolheMary Lieh-Lai
Jun 24, 2003·Journal of Pharmaceutical Sciences·Monica L AdamsGlen S Kwon
Jul 8, 2003·Clinical Pharmacokinetics·Albert J ten TijeAlex Sparreboom
Jul 25, 2003·Expert Opinion on Pharmacotherapy·Raoul HerbrechtValérie Letscher-Bru
Jul 26, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eun Seong LeeYou Han Bae
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anatoly N LukyanovVladimir P Torchilin
Oct 14, 2003·Bioorganic & Medicinal Chemistry Letters·Yasutsugu UedaJoanne J Bronson
Nov 1, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Granero GladysLonghi Marcela
Dec 31, 2003·International Journal of Pharmaceutics·Gang YangSamuel H Yalkowsky
Mar 23, 2004·Pharmaceutical Research·Robert G Strickley
Apr 15, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyuk Sang Yoo, Tae Gwan Park

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Citations

Dec 28, 2012·International Journal of Nanomedicine·Dan LiQiang Zhang
Feb 13, 2014·Analytical and Bioanalytical Chemistry·Askell HinnaJudith Kuntsche
Mar 24, 2011·Journal of Microencapsulation·Yan LiDavid Julian McClements
Dec 24, 2011·Drug Development and Industrial Pharmacy·Stephanie Bosselmann, Robert O Williams
Jan 22, 2013·International Journal of Pharmaceutics·Biswadip SinhaJan P Möschwitzer
Dec 19, 2012·Colloids and Surfaces. B, Biointerfaces·Mi Kyung KimHyeon Gyu Lee
Sep 25, 2012·International Journal of Pharmaceutics·Jan P Möschwitzer
Dec 2, 2010·Advanced Drug Delivery Reviews·Jian ZhangWiwik Watanabe
Feb 12, 2014·International Journal of Pharmaceutics·Kelly EthersonMoira Elliott
Dec 10, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zimei WuDarren Svirskis
Oct 19, 2011·The Journal of Physical Chemistry. B·Nathan W LloydStephanie R Dungan
Feb 8, 2018·Drug Development and Industrial Pharmacy·Zahari VinarovSlavka S Tcholakova
May 31, 2018·AAPS PharmSciTech·Daniel J EllenbergerRobert O Williams
Feb 7, 2013·Pharmacological Reviews·Hywel D WilliamsChristopher J H Porter
Feb 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarzyna SzymczykJoanna Krawczyk
Nov 9, 2020·AAPS PharmSciTech·Deck Khong TanAli Nokhodchi
Jan 7, 2021·Drug Development and Industrial Pharmacy·Biswadip SinhaJan P Möschwitzer
Aug 10, 2021·International Journal of Pharmaceutics·Biswadip SinhaJan P Möschwitzer

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