Recent advances in kartogenin for cartilage regeneration

Journal of Drug Targeting
Gaorui CaiDaping Wang

Abstract

Either osteoarthritis or sports-related injuries can lead to cartilage defects, whereas both chondrocyte self-renewal and conventional treatments face limitations. In cartilage regenerative medicine, growth factors are commonly used to induce chondrogenic differentiation of stem cells. However, application of growth factors is confined by some drawbacks. Emerging small molecules are regarded as an alternative for cartilage regeneration. A recently discovered small-molecule compound, kartogenin (KGN), has been proven to be a chondrogenic and chondroprotective agent and is more effective in inducing cartilage regeneration when compared with growth factors. KGN has been processed and applied in many forms, such as in intra-articular injection, in collaboration with growth factors, in incorporation in drug delivery systems, and in combination with scaffolds. Fortunately, progress has been achieved in KGN applications. The current review discusses the recent advances in KGN for cartilage regeneration and thus presents new concepts in cartilage repair in clinical settings.

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Citations

Jan 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hui JingXiaomin He
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chang'an ChenJinzhong Zhao
Jul 13, 2019·Nature Reviews. Rheumatology·Heenam KwonKyriacos A Athanasiou
Jul 6, 2020·BMC Musculoskeletal Disorders·Anand O Masson, Roman J Krawetz
Feb 26, 2021·Stem Cells International·Shuangpeng JiangQuanyi Guo
Aug 29, 2021·International Journal of Pharmaceutics·Ayesha YounasNan Zhang

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