Recent advances in microbial production of mannitol: utilization of low-cost substrates, strain development and regulation strategies

World Journal of Microbiology & Biotechnology
Min ZhangMin Jiang

Abstract

Mannitol has been widely used in fine chemicals, pharmaceutical industries, as well as functional foods due to its excellent characteristics, such as antioxidant protecting, regulation of osmotic pressure and non-metabolizable feature. Mannitol can be naturally produced by microorganisms. Compared with chemical manufacturing, microbial production of mannitol provides high yield and convenience in products separation; however the fermentative process has not been widely adopted yet. A major obstacle to microbial production of mannitol under industrial-scale lies in the low economical efficiency, owing to the high cost of fermentation medium, leakage of fructose, low mannitol productivity. In this review, recent advances in improving the economical efficiency of microbial production of mannitol were reviewed, including utilization of low-cost substrates, strain development for high mannitol yield and process regulation strategies for high productivity.

References

Jul 1, 1987·Journal of General Microbiology·D E Quain, C A Boulton
Mar 1, 1987·Applied Biochemistry and Biotechnology·H K Chenault, G M Whitesides
Jan 5, 2002·Expert Opinion on Investigational Drugs·S I Rapoport
Jun 25, 2002·Journal of Industrial Microbiology & Biotechnology·Niklas von WeymarnM Leisola
Apr 19, 2003·FEMS Yeast Research·Roeland CostenobleGunnar Lidén
Feb 15, 2005·Journal of Biotechnology·Miia HelantoMatti Leisola
Mar 5, 2005·Applied and Environmental Microbiology·H Wouter WisselinkJeroen Hugenholtz
Apr 21, 2005·Applied Microbiology and Biotechnology·Björn KaupHermann Sahm
Mar 15, 2006·Applied Microbiology and Biotechnology·Badal C Saha
Jun 1, 2006·Journal of Industrial Microbiology & Biotechnology·Badal C Saha
Oct 15, 2008·Bioprocess and Biosystems Engineering·Cláudia P M L FontesSueli Rodrigues
Jul 7, 2009·Applied Microbiology and Biotechnology·Seung Hoon Song, Claire Vieille
Apr 3, 2010·Applied Microbiology and Biotechnology·Badal C Saha, F Michael Racine
Nov 11, 2010·Applied Microbiology and Biotechnology·Badal C Saha, F Michael Racine
Jun 1, 2012·Journal of Industrial Microbiology & Biotechnology·Ludwika TomaszewskaWitold Gładkowski
Jan 1, 2014·Journal of Bioscience and Bioengineering·Jun YoshikawaDai Kitamoto
Aug 26, 2016·Applied Biochemistry and Biotechnology·Qing MengMing Miao
May 17, 2017·Journal of Industrial Microbiology & Biotechnology·Min ZhangPingkai Ouyang

❮ Previous
Next ❯

Citations

Apr 25, 2020·Microorganisms·Patrick FickersCarol Sze Ki Lin
Apr 18, 2020·Critical Reviews in Biotechnology·Gheorghe Adrian MartăuDan Cristian Vodnar
Jul 8, 2020·Biological Trace Element Research·Marek Kieliszek, Marianna Dourou
Jan 1, 2020·Biotechnology for Biofuels·Yinghang LiuJin Hou
Apr 7, 2021·Journal of Bacteriology·Kathleen N McAllisterJoseph A Sorg
Jul 31, 2021·Critical Reviews in Biotechnology·Ge ZhangZongjie Dai
Apr 3, 2020·Journal of Agricultural and Food Chemistry·Hang XiaoProf Christian Solem

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Related Papers

Journal of the Science of Food and Agriculture
Nur Ain Zamzuri, Suraini Abd-Aziz
Applied Microbiology and Biotechnology
Seung Hoon Song, Claire Vieille
Zeitschrift für allgemeine Mikrobiologie
L WünscheU Behrens
© 2022 Meta ULC. All rights reserved