Recent Advances in Microfluidics for the Preparation of Drug and Gene Delivery Systems.

Molecular Pharmaceutics
Mhd Anas Tomeh, Xiubo Zhao

Abstract

Drug delivery systems (DDSs) have great potential for improving the treatment of several diseases, especially microbial infections and cancers. However, the formulation procedures of DDSs remain challenging, especially at the nanoscale. Reducing batch-to-batch variation and enhancing production rate are some of the essential requirements for accelerating the translation of DDSs from a small scale to an industrial level. Microfluidic technologies have emerged as an alternative to the conventional bench methods to address these issues. By providing precise control over the fluid flows and rapid mixing, microfluidic systems can be used to fabricate and engineer different types of DDSs with specific properties for efficient delivery of a wide range of drugs and genetic materials. This review discusses the principles of controlled rapid mixing that have been employed in different microfluidic strategies for producing DDSs. Moreover, the impact of the microfluidic device design and parameters on the type and properties of DDS formulations was assessed, and recent applications in drug and gene delivery were also considered.

References

May 17, 2001·Analytical Chemistry·B HeF E Regnier
Jan 26, 2002·Science·Abraham D StroockGeorge M Whitesides
Apr 12, 2003·Nature Materials·Daniel TherriaultJennifer A Lewis
Oct 4, 2003·Physical Review Letters·Brian K Johnson, Robert K Prud'homme
Mar 5, 2004·Journal of the American Chemical Society·Andreas JahnLaurie E Locascio
Jul 23, 2004·Lab on a Chip·Axel GüntherKlavs F Jensen
Feb 9, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Axel GüntherKlavs F Jensen
Jul 4, 2006·Pharmacology & Therapeutics·Nobuhiro Nishiyama, Kazunori Kataoka
Nov 30, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Marian E GindyRobert K Prud'homme
May 27, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Xiubo ZhaoJian R Lu
Jul 29, 2008·Nano Letters·Rohit KarnikOmid C Farokhzad
Apr 16, 2009·The Journal of Physical Chemistry. B·Ting ChenAthanassios Z Panagiotopoulos
Jun 23, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·James S MurdayJ Fraser Wright
Jun 26, 2009·Molecular Pharmaceutics·Chee Guan KohL James Lee
Jun 26, 2009·Expert Opinion on Drug Delivery·Xiubo ZhaoJian R Lu
Aug 1, 2009·Angewandte Chemie·Sadao OtaShoji Takeuchi
Jan 1, 2008·Biomicrofluidics·Zhiyi ZhangXudong Cao
Feb 12, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Catherine T LoWyatt N Vreeland
Apr 2, 2010·ACS Nano·Andreas JahnMichael Gaitan
May 14, 2011·Advanced Drug Delivery Reviews·Suzanne M D'Addio, Robert K Prud'homme
Jan 19, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Hui XieJeffrey W Smith
Jan 31, 2012·International Journal of Nanomedicine·Lorenzo CaprettoClaudio Nastruzzi
Apr 6, 2012·Journal of the American Chemical Society·Delai ChenDaniel G Anderson
Apr 19, 2012·Lab on a Chip·Wynter J DuncansonDavid A Weitz
Sep 8, 2012·Pharmaceutical Research·Oguzhan GunduzMohan Edirisinghe
Oct 9, 2012·Nature Nanotechnology·Pedro M ValenciaRobert Langer
Nov 20, 2012·Electrophoresis·Yung-Sheng LinChen-Ling Hsieh
Apr 9, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·James O HardinValeria T Milam
Aug 13, 2013·Advanced Drug Delivery Reviews·Stefania MazzitelliClaudio Nastruzzi
Aug 24, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Jong-Min LimRohit Karnik
May 31, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Charlene M DawidczykPeter C Searson
Jul 16, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Shing Fung ChowAlbert Hee Lum Chow
Dec 3, 2014·Advanced Drug Delivery Reviews·Huiyuan WangYongzhuo Huang
Dec 30, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Andreas WickiJörg Huwyler
Feb 12, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Masahiro MizunoMinoru Seki

❮ Previous
Next ❯

Citations

Mar 29, 2021·Journal of Colloid and Interface Science·Mhd Anas TomehXiubo Zhao
Jul 13, 2021·Frontiers in Bioengineering and Biotechnology·Aurelio Salerno, Paolo A Netti
Jul 7, 2021·Analytical Chemistry·Nino F LäubliBradley J Nelson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Sequencing

Several sequencing approaches are employed to understand and examine tumor development and progression. These include whole genome as well as RNA sequencing. Here is the latest research on cancer sequencing.