PMID: 2496882Jan 1, 1989Paper

Recent advances in molecular biology of chronic myeloid leukaemia: is the pathogenetic puzzle approaching solution?

Bone Marrow Transplantation
J M Goldman

Abstract

The great majority of patients with chronic myeloid leukaemia (CML) have a Philadelphia (Ph) chromosome which has proved at molecular level to be associated with the production of chimeric BCR-ABL gene which in turn is expressed as a fusion protein (P210) with tyrosine kinase activity. An equivalent but somewhat smaller chimeric gene and fusion protein (P190) is found in some cases of Ph-positive acute leukaemia. Though the consistency of these abnormal findings in patients with Ph-positive leukaemia is strong evidence for their pathogenetic role, there are still many unanswered questions.

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