Recent Advances in Nanotechnology for Dendritic Cell-Based Immunotherapy

Frontiers in Pharmacology
Chen QianHong Cui

Abstract

Dendritic cells (DCs) are the most important antigen-presenting cells that determine cancer immune responses by regulating immune activation and tolerance, especially in the initiation stage of specific responses. Manipulation of DCs to enhance specific antitumor immune response is considered to be a powerful tool for tumor eradication. Nanotechnology, which can incorporate multifunction components and show spatiotemporal control properties, is of great interest and is widely investigated for its ability to improve immune response activity against cancer and even for prevention and avoiding recurrence. In this mini-review, we aim to provide a general view of DC-based immunotherapy, including that involving the promising nanotechnology. Particularly we discuss: (1) manipulation or engineering of DCs for adoptive vaccination, (2) employing DCs as a combination to more existing therapeutics in tumor treatment, and (3) direct modulation of DCs in vivo to enhance antigen presentation efficacy and priming T cells subsequently. We comprehensively discuss the updates on the application of nanotechnology in DC-based immunotherapy and provide some insights on the challenges and opportunities of DC-based immunotherapeutics, including the ...Continue Reading

References

Mar 14, 1991·The New England Journal of Medicine·J E KrookJ A Mailliard
Jun 13, 1991·The New England Journal of Medicine·UNKNOWN Department of Veterans Affairs Laryngeal Cancer Study GroupWilliam G Henderson
Mar 1, 1996·Stem Cells·R Thomas, P E Lipsky
Dec 2, 1999·Vaccine·W W LeitnerN P Restifo
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M SchnurrA Eigler
Dec 12, 2001·Trends in Immunology·C ArdavínH Hernández
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen BethkeMichael Heike
Jul 24, 2003·Nature Reviews. Immunology·Carlos Ardavín
Dec 10, 2003·The Lancet Oncology·J C CoffeyH P Redmond
Jan 9, 2004·Nature·Thorsten R MempelUlrich H Von Andrian
Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group
Feb 3, 2005·Nature Immunology·Hans Christian ProbstMaries van den Broek
May 11, 2006·Blood·Sergio RutellaGiuseppe Leone
Mar 10, 2007·Current Molecular Medicine·Gary T Jennings, Martin F Bachmann
May 23, 2007·Autoimmunity·Angela RaucciMarco E Bianchi
Sep 18, 2007·Nature Biotechnology·Sai T ReddyJeffrey A Hubbell
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angelo A ManfrediAlessandro Del Maschio
Aug 6, 2008·Arzneimittel-Forschung·Theodor H LippertManfred Volm
Nov 26, 2008·Handbook of Experimental Pharmacology·Alfonso Martín-FontechaFederica Sallusto
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Norimitsu Kadowaki
Apr 4, 2009·Current Opinion in Immunology·Elodie Segura, José A Villadangos
Sep 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gopal Murugaiyan, Bhaskar Saha
Sep 8, 2010·The New England Journal of Medicine·Philip W KantoffUNKNOWN IMPACT Study Investigators
Sep 16, 2010·Journal of Immunotherapy·Daniel E SpeiserMartin F Bachmann
Oct 16, 2010·Nature Reviews. Immunology·Martin F Bachmann, Gary T Jennings
May 20, 2011·European Urology·Himisha BeltranIan F Tannock
Jun 7, 2011·The New England Journal of Medicine·Caroline RobertJedd D Wolchok
Aug 27, 2011·Immunity·Nu Zhang, Michael J Bevan
Mar 1, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vincent KoppelmansSanne B Schagen
Mar 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daimon P SimmonsClifford V Harding
Jul 12, 2012·Nature Biotechnology·Bissan Al-LazikaniPaul Workman
Jan 29, 2013·Immunity·Elodie SeguraSebastian Amigorena
Mar 19, 2013·Expert Review of Vaccines·Pawel KalinskiJulie Urban
Oct 24, 2013·Nature Materials·Darrell J IrvineGregory L Szeto
Dec 21, 2013·Nature Communications·Jesse W WilliamsAnne I Sperling
Dec 21, 2013·Science·Jennifer Couzin-Frankel

❮ Previous
Next ❯

Citations

Oct 9, 2021·Clinical Science·Laura MarongiuFrancesca Granucci

❮ Previous
Next ❯

Methods Mentioned

BETA
exome sequencing

Clinical Trials Mentioned

NCT02334735
NCT00045968
NCT03688178
NCT03657966
NCT03047525
NCT03226236
NCT03546426
NCT03735290
NCT03450044
NCT03735589

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

© 2021 Meta ULC. All rights reserved