Recent advances in neuromuscular block during anesthesia

F1000Research
Martijn BoonAlbert Dahan

Abstract

Muscle relaxation is a routine part of anesthesia and has important advantages. However, the lingering effects of muscle relaxants in the postoperative period have historically been associated with postoperative adverse events. Neuromuscular reversal, together with neuromuscular monitoring, is a recognized strategy to reduce the rate of postoperative residual relaxation but has only marginally improved outcome in the past few decades. Sugammadex, a novel reversal agent with unique encapsulating properties, has changed the landscape of neuromuscular reversal and opened up new opportunities to improve patient care. By quickly and completely reversing any depth of neuromuscular block, it may reduce the rate of residual relaxation and improve respiratory recovery. In addition, sugammadex has made the use of deep neuromuscular block possible during surgery. Deep neuromuscular block may improve surgical working conditions and allow for a reduction in insufflation pressures during selected laparoscopic procedures. However, whether and how this may impact outcomes is not well established.

References

Oct 1, 1978·British Journal of Anaesthesia·G G Harrison
Oct 1, 1992·Acta Anaesthesiologica Scandinavica·L I ErikssonA Johnson
Oct 25, 1952·British Medical Journal·T C GRAY, G J REES
Jul 20, 2007·Acta Anaesthesiologica Scandinavica·T Fuchs-BuderUNKNOWN 8th International Neuromuscular Meeting
Jul 19, 2008·Anesthesia and Analgesia·Glenn S MurphyJeffery S Vender
Nov 19, 2009·Drug Design, Development and Therapy·Mark WelliverRobert Redfern
Mar 21, 2013·BMJ : British Medical Journal·Matthew J MeyerMatthias Eikermann
Jun 13, 2013·Anesthesia and Analgesia·Yoshifumi KotakeJunzo Takeda
Aug 16, 2014·Surgical Endoscopy·Manfred BlobnerHeidrun Fink
Jan 28, 2015·Anesthesia and Analgesia·Aaron F Kopman, Mohamed Naguib
Oct 9, 2015·Anesthesiology·Glenn S MurphyAashka Patel
Feb 6, 2016·Acta Anaesthesiologica Scandinavica·Aaron F Kopman, Mohamed Naguib

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Citations

Oct 27, 2020·NPJ Digital Medicine·Lorenzo SchiavoniFelice Eugenio Agrò

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