Recent Advances in Nucleic Acid Binding Aspects of Berberine Analogs and Implications for Drug Design

Mini Reviews in Medicinal Chemistry
Debipreeta Bhowmik, Gopinatha Suresh Kumar

Abstract

Berberine is one of the most widely known alkaloids belonging to the protoberberine group exhibiting myriad therapeutic properties. The anticancer potency of berberine appears to derive from its multiple actions including strong interaction with nucleic acids exhibiting adenine-thymine base pair specificity, inhibition of the enzymes topoisomerases and telomerases, and stabilizing the quadruplex structures. It was realized that the development of berberine as a potential anticancer agent necessitates enhancing its nucleic acid binding efficacy through appropriate structural modifications. More recently a number of such approaches have been attempted in various laboratories with great success. Several derivatives have been synthesized mostly with substitutions at the 8, 9 and 13 positions of the isoquinoline chromophore, and studied for enhanced nucleic acid binding activity. In this article, we present an up to date review of the details of the interaction of berberine and several of its important synthetic 8, 9 and 13 substituted derivatives with various nucleic acid structures reported recently. These studies provide interesting knowledge on the mode, mechanism, sequence and structural specificity of the binding of berberine ...Continue Reading

Citations

Aug 21, 2018·Journal of Cellular Biochemistry·AmirReza HesariAmirhossein Sahebkar
Aug 23, 2019·Beilstein Journal of Organic Chemistry·Qiaoqiao TengQi Meng
Nov 7, 2016·Journal of Pharmaceutical and Biomedical Analysis·Haihui ShenYingchun Liu
Apr 14, 2021·Bioorganic & Medicinal Chemistry·Sobhi GabaVikramdeep Monga
Aug 31, 2021·Expert Opinion on Therapeutic Patents·Yuan KongDong-Dong Li

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