Recent advances in oral delivery of peptide hormones

Expert Opinion on Drug Delivery
Pegah Varamini, Istvan Toth

Abstract

Oral delivery of therapeutic peptide hormones offers the promise of greater patient compliance when compared to parenteral administration routes. However, it is a huge challenge in the pharmaceutical field. Due to increasing demand for oral delivery of peptide hormones such as insulin, gonadotropin-releasing hormones, and calcitonin, various technologies have been explored to overcome the associated hurdles. This review article summarizes the physiological barriers to the oral delivery of peptide hormones and some of the key strategies to circumvent these barriers and enhance peptide hormones' oral bioavailability. In addition, recent advances in oral formulation strategies of peptide hormones, under development and within the clinical trial stages, are discussed. The pharmaceutical industry has devoted much effort to develop new, and often complex peptide hormone products based on formulation strategy. Use of the native structure of the peptide hormones in oral formulations could result in an unpredictable pharmacokinetic profile. Authors believe that considering chemical modification prior to formulation is essential to achieve orally active products. Although no major breakthrough has been achieved for effective oral deliver...Continue Reading

References

Sep 1, 1999·The Journal of Endocrinology·S E BastianD A Belford
Jun 6, 2000·Advanced Drug Delivery Reviews· T Borchardt RG M Pauletti
Oct 26, 2000·Pharmaceutical Science & Technology Today·P D WardD R Thakker
Mar 16, 2001·Expert Opinion on Pharmacotherapy·P Iglesias, J J Díez
Aug 11, 2001·Pharmaceutical Research·A Leone-BayR A Baughman
Mar 22, 2003·Protein Science : a Publication of the Protein Society·Han YanYou-Min Feng
Apr 2, 2003·Nature Reviews. Drug Discovery·Michael Goldberg, Isabel Gomez-Orellana
Dec 18, 2003·British Journal of Clinical Pharmacology·A A Mangoni, S H D Jackson
Apr 7, 2004·Journal of Pharmaceutical Sciences·Masataka KatsumaIan R Wilding
Aug 18, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·László B TankóClaus Christiansen
Mar 7, 2006·Advanced Drug Delivery Reviews·Noha N SalamaAlessio Fasano
Aug 4, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yu Seok YounKang Choon Lee
Jan 24, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kishore B ChalasaniSanjay K Jain
Dec 7, 2007·Pharmaceutical Research·Kathryn WhiteheadSamir Mitragotri
Dec 14, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Iain C Macdougall
Aug 5, 2009·Journal of Pharmaceutical Sciences·Timo KorjamoJukka Mönkkönen
Aug 26, 2009·Journal of Medicinal Chemistry·Claudio MapelliWilliam R Ewing
Sep 19, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nurmamet AmetWei-Chiang Shen
Jan 6, 2010·Journal of Pharmaceutical Sciences·Dipak S PisalSathy V Balu-Iyer
Feb 24, 2010·Journal of Pharmacological and Toxicological Methods·R RinkG N Moll
Mar 20, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Johan Van de WalleAnn Raes
Oct 12, 2010·MAbs·Janice M Reichert
Oct 12, 2010·Expert Opinion on Biological Therapy·Kim HenriksenMorten Asser Karsdal
Oct 16, 2010·Biotechnology Progress·Partha HazraHarish Iyer
Dec 28, 2010·International Journal of Pharmaceutics·Kailas KhomaneArvind Bansal
Apr 6, 2011·Journal of Pharmaceutical Sciences·Maria Dorly Del CurtoMaria Edvige Sangalli
Sep 22, 2011·Current Drug Metabolism·Filipa AntunesBruno Sarmento
Oct 27, 2011·Indian Journal of Endocrinology and Metabolism·Navneet Magon
Apr 1, 2010·Oman Medical Journal·Anil K Philip, Betty Philip
Mar 23, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Neil BinkleyUNKNOWN Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) Investigators
Jun 5, 2012·Pharmacology & Therapeutics·Young Min ChoTimothy J Kieffer
Jul 27, 2012·Therapeutic Delivery·David J Brayden, Randall J Mrsny
Jul 28, 2012·Therapeutic Delivery·Edgar P HerreroNoemi Csaba

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Citations

Jul 11, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jiang-Jiang QinRuiwen Zhang
Jan 22, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ann-Christin JacobsenAlexander H Treusch
May 8, 2018·Pharmaceuticals·Othman Al MusaimiFernando Albericio
Jan 12, 2019·Expert Opinion on Drug Delivery·Joana A D SequeiraAntónio J Ribeiro
Mar 15, 2020·International Journal of Molecular Sciences·Casati FedericaGazzaniga Andrea
Aug 24, 2017·Drug Development Research·David Gurwitz

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