Recent advances in peptides for enhancing transdermal macromolecular drug delivery

Therapeutic Delivery
Renquan RuanLongping Wen

Abstract

Transdermal delivery of drugs, a compelling route of systemic drug delivery, provides painless, reliable, targeted, efficient and cost effective therapeutic regimen for patients. However, its use is limited by skin barrier especially the stratum corneum barrier. Moreover, transdermal delivery of macromolecules remains a challenge. Naturally, varieties of physical methods, chemical enhancers and drug carriers have been used to counteract this limitation. Recently, transdermal peptides discovered as safer, more efficient and more specific enhancers could promote the delivery of macromolecules across the skin. Herein, the underlying transdermal peptides are included. Subsequently, we have discussed typical applications and the possible mechanism of two groups of biologically inspired transdermal peptide enhancers, namely cell penetration peptides and transdermal enhanced peptides.

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Citations

Jun 24, 2016·Pharmaceutical Patent Analyst·Hermann Am Mucke
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Sep 4, 2021·Drug Delivery and Translational Research·Lijuan ZengWenting Song

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Methods Mentioned

BETA
phage display
transmission electron microscopy
phage-display

Software Mentioned

SPACE

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