Recent advances in polymeric biomaterials-based gene delivery for cartilage repair

Bioactive Materials
Ran YangShifang Luan

Abstract

Untreated articular cartilage damage normally results in osteoarthritis and even disability that affects millions of people. However, both the existing surgical treatment and tissue engineering approaches are unable to regenerate the original structures of articular cartilage durably, and new strategies for integrative cartilage repair are needed. Gene therapy provides local production of therapeutic factors, especially guided by biomaterials can minimize the diffusion and loss of the genes or gene complexes, achieve accurate spatiotemporally release of gene products, thus provideing long-term treatment for cartilage repair. The widespread application of gene therapy requires the development of safe and effective gene delivery vectors and supportive gene-activated matrices. Among them, polymeric biomaterials are particularly attractive due to their tunable physiochemical properties, as well as excellent adaptive performance. This paper reviews the recent advances in polymeric biomaterial-guided gene delivery for cartilage repair, with an emphasis on the important role of polymeric biomaterials in delivery systems.

Citations

Jan 4, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yu Seon Kim, Antonios G Mikos
Mar 30, 2021·Biologics : Targets & Therapy·Tafere Mulaw Belete
Aug 17, 2021·Physical and Engineering Sciences in Medicine·Srilakshmi PrabhuS B Gudennavar

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Methods Mentioned

BETA
transfection
flow cytometry
phage display
transgenic
GAM
Scanning electron microscopy
transfect
antisense oligonucleotides
biopsy

Software Mentioned

Pro Plus
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