Oct 16, 2015

Recent advances in recombinant protein-based malaria vaccines

Vaccine
Simon J DraperSumi Biswas

Abstract

Plasmodium parasites are the causative agent of human malaria, and the development of a highly effective vaccine against infection, disease and transmission remains a key priority. It is widely established that multiple stages of the parasite's complex lifecycle within the human host and mosquito vector are susceptible to vaccine-induced antibodies. The mainstay approach to antibody induction by subunit vaccination has been the delivery of protein antigen formulated in adjuvant. Extensive efforts have been made in this endeavor with respect to malaria vaccine development, especially with regard to target antigen discovery, protein expression platforms, adjuvant testing, and development of soluble and virus-like particle (VLP) delivery platforms. The breadth of approaches to protein-based vaccines is continuing to expand as innovative new concepts in next-generation subunit design are explored, with the prospects for the development of a highly effective multi-component/multi-stage/multi-antigen formulation seeming ever more likely. This review will focus on recent progress in protein vaccine design, development and/or clinical testing for a number of leading malaria antigens from the sporozoite-, merozoite- and sexual-stages of...Continue Reading

Mentioned in this Paper

Plasmodium
Mosquito Vectors
Merozoites
Pfs25 protein, Plasmodium falciparum
RH5 protein, Plasmodium falciparum
Immunologic Adjuvants
Clinical Enzyme Tests (Procedure)
Vaccines
Adjuvant
Proteins, Recombinant DNA

Related Feeds

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Related Papers

The Journal of Infectious Diseases
John T Schiller, Douglas R Lowy
Asian Pacific Journal of Allergy and Immunology
Victor Nussenzweig, Ruth Nussenzweig
Expert Reviews in Molecular Medicine
Ruobing WangStefan H I Kappe
© 2020 Meta ULC. All rights reserved