Recent advances in skin 'barrier' research

The Journal of Pharmacy and Pharmacology
Anthony V Rawlings

Abstract

Our knowledge on the complexity of stratum corneum biology, chemistry and biophysics has grown over the last decade. This and the intricate control mechanisms in the stratum corneum that bring about its full and proper structural maturity will be reviewed. The importance of the total architecture of the stratum corneum in relation to desquamation and barrier function, the role of the corneodesmosomes and their degrading enzymes, new insights into the importance of natural moisturising factor and the emerging knowledge on the chemical antimicrobial barrier of the stratum corneum are discussed. Despite our increasing knowledge of the complexity of stratum corneum, we are still far from understanding its intricate control mechanisms that bring about its maturity and desquamation.

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Citations

Sep 23, 2014·The British Journal of Dermatology·A V Rawlings
Jun 13, 2018·Experimental Dermatology·Ivone JakasaSanja Kezic
Oct 12, 2012·Cell and Tissue Research·Anthony V Rawlings, Rainer Voegeli
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Aug 14, 2019·Journal of the American Society for Mass Spectrometry·Guillaume HochartGeorgios N Stamatas
Aug 12, 2021·British Journal of Nursing : BJN·David Voegeli, Sarah Hillery

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