Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot

Advances in Colloid and Interface Science
Gesmi MilcovichSilvia Giordani

Abstract

Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehensive understanding of the processes involved in the self-assembly of the colloidal structures discussed therein is essential for the development of relevant biomedical applications. In this review we report the most promising and best performing platforms for specific classes of bioactive molecules and related target, spanning from siRNAs, gene/plasmids, proteins/growth factors, small synthetic therapeutics and bioimaging probes.

Citations

May 2, 2018·Biomaterials Science·Mehdi KhanmohammadiJafar Ai
Jul 24, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chunhua YangDidier Merlin
Nov 5, 2019·Frontiers in Chemistry·Dao-Yang FanZhong-Jun Liu
Dec 19, 2020·Open Medicine·Sante Di GioiaMassimo Conese
Feb 2, 2021·Colloids and Surfaces. B, Biointerfaces·Yin XiaoXiaoai He
Aug 29, 2020·Journal of Colloid and Interface Science·Joan Puig-RigallGustavo González-Gaitano

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