Recent advances in synthesis and surface modification of lanthanide-doped upconversion nanoparticles for biomedical applications

Biotechnology Advances
Min LinTianJian Lu

Abstract

Lanthanide (Ln)-doped upconversion nanoparticles (UCNPs) with appropriate surface modification can be used for a wide range of biomedical applications such as bio-detection, cancer therapy, bio-labeling, fluorescence imaging, magnetic resonance imaging and drug delivery. The upconversion phenomenon exhibited by Ln-doped UCNPs renders them tremendous advantages in biological applications over other types of fluorescent materials (e.g., organic dyes, fluorescent proteins, gold nanoparticles, quantum dots, and luminescent transition metal complexes) for: (i) enhanced tissue penetration depths achieved by near-infrared (NIR) excitation; (ii) improved stability against photobleaching, photoblinking and photochemical degradation; (iii) non-photodamaging to DNA/RNA due to lower excitation light energy; (iv) lower cytotoxicity; and (v) higher detection sensitivity. Ln-doped UCNPs are therefore attracting increasing attentions in recent years. In this review, we present recent advances in the synthesis of Ln-doped UCNPs and their surface modification, as well as their emerging applications in biomedicine. The future prospects of Ln-doped UCNPs for biomedical applications are also discussed.

References

Oct 6, 1998·Annual Review of Biochemistry·R Y Tsien
Jan 12, 2001·Analytical Biochemistry·J HamplD E Cooper
Mar 27, 2001·Accounts of Chemical Research·S Feng, R Xu
May 25, 2001·Analytical Biochemistry·R S NiedbalaR Vallejo
May 31, 2003·Science·Daniel R LarsonWatt W Webb
Jun 2, 2005·Nature Materials·Igor L MedintzHedi Mattoussi
May 11, 2006·Journal of the American Chemical Society·Hao-Xin MaiChun-Hua Yan
Jun 17, 2006·Chemical Communications : Chem Comm·Leyu Wang, Yadong Li
Sep 21, 2006·Journal of the American Chemical Society·Peng ZhangDamon Wheeler
Mar 28, 2007·Journal of the American Chemical Society·Peng ZhangMatthew Scholfield
Oct 19, 2007·Journal of Clinical Microbiology·Paul L A M CorstjensGovert J van Dam
Apr 29, 2008·Chemical Communications : Chem Comm·Mengxiao YuChunhui Huang
Jul 4, 2008·Annals of the New York Academy of Sciences·Tero SoukkaKatri Kuningas
Jul 26, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Masao KamimuraYukio Nagasaki
Aug 5, 2008·Biomaterials·Rufaihah Abdul Jalil, Yong Zhang
Feb 12, 2009·ACS Nano·Oliver EhlertThomas Nann
Feb 17, 2009·Chemistry : a European Journal·He HuChunhui Huang
May 8, 2009·Chemical Society Reviews·Feng Wang, Xiaogang Liu
Jun 18, 2009·Chemical Communications : Chem Comm·Shu-Zhuo ZhangChun-Hua Yan
Jun 23, 2009·Biomaterials·Niagara Muhammad IdrisYong Zhang
Jul 9, 2009·Chemical Communications : Chem Comm·Scott A HilderbrandRalph Weissleder
Aug 27, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Zewei QuanJun Lin
Sep 10, 2009·Nanotechnology·Shuang Fang LimRobert H Austin
Sep 22, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Zhengquan LiNiagara Muhammad Idris
Oct 8, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Ya-Ping DuChun-Hua Yan
Oct 9, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·John-Christopher BoyerFrank C J M van Veggel
Oct 30, 2009·Chemical Communications : Chem Comm·Xiaomin LiuHong Zhang
Dec 17, 2009·Chemical Reviews·Hisataka KobayashiYasuteru Urano
Jan 16, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Shan Jiang, Yong Zhang
Mar 17, 2010·Chemical Reviews·Angelique Louie

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Citations

May 28, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Lokman UzunAdil Denizli
Jul 6, 2014·PLoS Neglected Tropical Diseases·Paul L A M CorstjensUNKNOWN Cysticercosis Working Group in Peru
Nov 16, 2013·Pathology Oncology Research : POR·Yongjiang YuJun Qi
Jan 21, 2014·Academic Radiology·Sheng-Min LanRuey-Mo Lin
Aug 6, 2015·Chemical Reviews·Kenneth K Ng, Gang Zheng
Nov 2, 2015·Advances in Colloid and Interface Science·Min LinZhenfeng Duan
Oct 13, 2015·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Tomasz GrzybStefan Lis
Oct 15, 2013·Advanced Drug Delivery Reviews·Numfon KhemthongcharoenWibool Piyawattanametha
Sep 2, 2014·Biochemical Pharmacology·Fanny CaputoLina Ghibelli
May 31, 2016·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Samantha J ChadwickMartin Volk
Mar 17, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ajmeeta SangtaniJames B Delehanty
Mar 28, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Yuying LiuLi Xu
Oct 11, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Tomasz GrzybStefan Lis
Oct 21, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Naushad AhmedMaheswaran Shanmugam
Jun 24, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan WeiXuliang Deng
Sep 2, 2014·Chemical Society Reviews·Anna GnachJohn A Capobianco
Nov 4, 2017·Chemical Communications : Chem Comm·Pingyu ZhangHui Chao
Jan 28, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Tomasz GrzybStefan Lis
Jan 22, 2015·Macromolecular Rapid Communications·Mei Xiang WangYong Mei Chen
Oct 24, 2018·Journal of Biophotonics·Padmaja P NampiSikha Saha
Dec 21, 2018·Methods and Applications in Fluorescence·Gabrielle A MandlJohn A Capobianco
Mar 27, 2015·Macromolecular Rapid Communications·Ziyong Cheng, Jun Lin
Feb 20, 2019·Angewandte Chemie·Carolina A FerreiraWeibo Cai
Dec 21, 2019·Nanoscale·Roger M Pallares, Rebecca J Abergel
Jul 9, 2020·Advanced Materials·Hui LiGuanying Chen
Dec 24, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Arik KarAmitava Patra
Mar 7, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Srigurunathan Kalaivani, Sanjeevi Kannan
Mar 31, 2015·Nanoscale·Bennett E SmithPeter J Pauzauskie

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