May 8, 2019

Recent advances in synthetic pharmacotherapies for dyslipidaemias

European Journal of Preventive Cardiology
Cesare R SirtoriM Ruscica

Abstract

Despite the demonstrated benefits of statins and injectable biologics, there is a need for new and safe oral agents for addressing classical lipid targets, low-density lipoprotein cholesterol (LDL-C), triglycerides and high-density lipoprotein cholesterol (HDL-C). LDL-C is unquestionably causal in the development of atherogenesis and atherosclerotic cardiovascular disease, but new options are required to address triglyceride-rich lipoproteins and lipoprotein(a). For hypercholesterolaemia, pitavastatin provides a very low dose and potent statin that does not adversely affect glucose metabolism; bempedoic acid acts at a biochemical step preceding hydroxymethylglutaryl-CoA reductase and is not associated with muscular side effects. For hypertriglyceridaemia, pemafibrate displays a unique and selective agonist activity on peroxisomal proliferator activated receptor-α that does not elevate homocysteine or creatinine. Although omega-3 fatty acids supplementation is not effective in secondary prevention, high dose eicosapentaenoic ethyl ester can lead to a remarkable fall in first and recurrent events in high risk patients with hypertriglyceridaemia/low HDL-C. Gemcabene, a dicarboxylic acid regulating apolipoprotein B-100, is effectiv...Continue Reading

  • References114
  • Citations4

Citations

Mentioned in this Paper

Creatinine
Injection Product
Peroxisome Proliferator-Activated Receptors
CETP protein, human
Icosapent ethyl
Omega-3 Fatty Acids
Anticoagulants, Oral
Hydroxymethylglutaryl-CoA reductase
Hypercholesterolemia
Dicarboxylic Acids

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