Recent advances in targeting DNA repair pathways for the treatment of ovarian cancer and their clinical relevance

International Journal of Clinical Oncology
Katsutoshi OdaTomoyuki Fujii

Abstract

Poly (ADP-ribose) polymerase (PARP) inhibitors have attracted much attention as one of the major molecular-targeted therapeutics for inhibiting DNA damage response. The PARP inhibitor, olaparib, has been clinically applied for treating certain recurrent ovarian cancer patients with BRCA1/2 mutations in Europe and the United States. It was also designated on 24 March 2017 as an orphan drug in Japan for similar clinical indications. In this review, we discuss (i) the prevalence of BRCA1/2 mutations in ovarian cancer, (ii) clinical trials of PARP inhibitors in ovarian cancer, (iii) genetic counseling for hereditary breast and ovarian cancer patients, and (iv) non-BRCA genes that may be associated with homologous recombination deficiency.

References

Mar 31, 2000·American Journal of Human Genetics·R MoslehiS A Narod
May 18, 2000·Journal of the National Cancer Institute·K K Khanna
Mar 10, 2001·Nature Genetics·K K Khanna, S P Jackson
Sep 14, 2001·Progress in Nucleic Acid Research and Molecular Biology·A E TomkinsonT A Motycka
May 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cherrie K DonawhoDavid J Frost
Jun 19, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Pål MøllerAnita Vabø
Mar 18, 2008·Current Opinion in Genetics & Development·Sarah A MartinAlan Ashworth
Jun 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marie SoegaardSusan J Ramus
Jun 26, 2008·Human Genetics·Philippe M CampeauMarc D Tischkowitz
Jul 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alan Ashworth
Oct 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sven RottenbergJos Jonkers
Jun 26, 2009·The New England Journal of Medicine·Peter C FongJohann S de Bono
Oct 8, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emma BoldersonKum Kum Khanna
Apr 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charlie GourleyMichelle Ferguson
Jan 6, 2011·CA: a Cancer Journal for Clinicians·Timothy A YapJohann S de Bono
Jul 2, 2011·Nature·UNKNOWN Cancer Genome Atlas Research Network
Jul 8, 2011·The Journal of Pathology·Paul M WilkersonJorge S Reis-Filho
Aug 9, 2011·Nature Genetics·Chey LovedayNazneen Rahman
Oct 4, 2011·Nature Genetics·Thorunn RafnarKari Stefansson
Oct 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Tom WalshElizabeth M Swisher
Dec 20, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Clayton R HuntTej K Pandita
Jan 26, 2012·JAMA : the Journal of the American Medical Association·Kelly L BoltonUNKNOWN Cancer Genome Atlas Research Network
Mar 29, 2012·The New England Journal of Medicine·Jonathan LedermannUrsula Matulonis
Apr 28, 2012·Nature Genetics·Chey LovedayNazneen Rahman
Jun 20, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn AlsopGillian Mitchell
Jun 26, 2012·Clinical Genetics·F CouletF Soubrier
Nov 19, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kathryn P PenningtonElizabeth M Swisher
Dec 21, 2013·Gynecologic Oncology·Christine GarciaC Bethan Powell
Nov 5, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bella KaufmanSusan M Domchek
Nov 16, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Francisco J Candido-dos-ReisUNKNOWN Australian Ovarian Cancer Study Group
May 30, 2015·Breast Cancer Research and Treatment·Christopher SchroederAndreas Rump

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